کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5831069 1559651 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea
چکیده انگلیسی

Bioassay-guided fractionation of the ethanol extract of the Chinese folk medicine Crotalaria ferruginea led to the isolation of a new isoflavonoid, 4′-hydroxy-2′-methylalpinum-isoflavone (1), and eight known analogs (2-9). Their structures were elucidated by spectroscopic analysis. Compounds 1, 2, 5, and 8 showed inhibitory activities against phosphodiesterase-4 (PDE4), a therapeutic target of asthma, with IC50 values ranging from 2.57 to 8.94 μM. The possible action mechanism and the structure-activity relationship (SAR) of the active isoflavonoids were explored by using molecular docking and molecular dynamics (MD) simulation methods. Our study herein may explain the anti-inflammatory function of this plant in Chinese folk medicine.

146

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 94, April 2014, Pages 177-182
نویسندگان
, , , , , , , ,