Keywords: NCT01433666; EudraCT2011-002070-23; Roflumilast; PDE4; cAMP; Memory; Verbal learning task;
مقالات ISI (ترجمه نشده)
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Keywords: Pyridazinone; Phosphodiesterase inhibitors; Anti-inflammatory; PDE4;
Keywords: AD; atopic dermatitis; AUC24; area under the concentration-time curve from 0 to 24Â h; cAMP; cyclic adenosine monophosphate; CMC; carboxymethylcellulose; ECAC; Executive Carcinogen Advisory Committee; ICH; International Conference on Harmonization; IgE; i
Keywords: atopic dermatitis; crisaborole; eczema; long-term safety; ointment; PDE4; phosphodiesterase-4; topical treatment; AD; atopic dermatitis; AE; adverse event; ISGA; Investigator's Static Global Assessment; PDE4; phosphodiesterase-4; SAE; serious adverse even
Keywords: Ethanol; PDE4; cAMP; PKA
Keywords: RSV; resveratrol (3,5,4â²-trihydroxy-trans-stilbene); SIRT1; sirtuin 1; PDE4; phosphodiesterase 4; ROS; reactive oxygen species; HNE; 4-hydroxy-2-nonenal; GSH; glutathione; KBM; keratinocyte basal medium; KGM; keratinocyte growth medium; NHEK; neonatal n
Keywords: PDE4; Diabetic nephropathy; Calorie restriction; AMPK and SIRT1;
Keywords: Palladium; Pyrroloquinoxaline; PDE4; Apoptosis; Zebrafish
Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies
Keywords: Ketamine; microRNA; Prefrontal cortex; Small interfering RNA; RNA interference; 5-HT; serotonin; 5-HT1A receptor; serotonin 1A receptor; A1; adenosine A1 receptor; AchE; acetylcholinesterase; AGO; argonaute; Akt-mTOR; protein kinase B/Akt- mammalian targe
The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion
Keywords: Bax; Bcl-2 associated x protein; Bcl-2; B-cell lymphoma-2; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; CREB; cAMP-response element binding protein; GFAP; glial fibrillary acidic protein; H&E; haematoxylin and eosin; Iba-1; ionized c
The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1
Keywords: RACK1; Receptor for activated C-kinase; PRMT1; Protein arginine N-methyltransferase 1; CHD-3; Chromo-helicase-DNA-binding domain protein 3; PGRMC1; Progesterone receptor membrane component 1; RACK1; SERBP1; HABP4; 2-Hybrid; PDE4D5; PDE4;
Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays
Keywords: High-throughput; Phosphodiesterase; PDE4; PDE7; Inflammation; Schizosaccharomyces pombe;
Reduced COPD Exacerbation Risk Correlates With Improved FEV1
Keywords: COPD exacerbations; COPD mechanisms; COPD pharmacology; BD; bronchodilator; dFEV1; between-group difference in change in predose (trough) FEV1 from the beginning to the end of the trial; HR; hazard ratio; non-BD; nonbronchodilator; PDE4; phosphodiesterase
Uncovering the function of Disrupted in Schizophrenia 1 through interactions with the cAMP phosphodiesterase PDE4: Contributions of the Houslay lab to molecular psychiatry
Keywords: DISC1; Disrupted in Schizophrenia 1; PDE4; phosphodiesterase type 4; NDE1; nuclear distribution element 1; NDEL1; NDE-like 1; iPS; induced pluripotent stem cells; DISC1; PDE4; Schizophrenia;
The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses
Keywords: PDE4; PDE4 inhibition; Roflumilast; Rolipram; Cognition; Memory; Emesis; cAMP
OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD): A phase-II randomized, double-blind, placebo-controlled study
Keywords: atopic dermatitis; atopic eczema; OPA-15406; phosphodiesterase type 4 inhibitor; topical agents; topical calcineurin inhibitor; AD; atopic dermatitis; BSA; body surface area; DLQI; Dermatology Life Quality Index; EASI; Eczema Area and Severity Index; IGA;
The phosphodiesterase 4 inhibitor roflumilast augments the Th17-promoting capability of dendritic cells by enhancing IL-23 production, and impairs their T cell stimulatory activity due to elevated IL-10
Keywords: cAMP; PDE4; PKA; Dendritic cells; IL-17; T cells
Original articleEfficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults
Keywords: atopic dermatitis; crisaborole ointment; eczema; phosphodiesterase 4; pruritus; topical therapy; AD; atopic dermatitis; AE; adverse event; ISGA; Investigator's Static Global Assessment; MedDRA; Medical Dictionary for Regulatory Activities; PDE4; phosphodi
RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5
Keywords: PDE4; PKA; ERK1/2; MK2; β2-adrenergic receptors; Acrodysostosis;
PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita
Keywords: Akt; RAC-alpha serine/threonine-protein kinase; COL7; type VII collagen; EBA; epidermolysis bullosa acquisita; IC; immune complex; MAPK; mitogen-activated protein kinase; PD; pemphigoid disease; PDE4; phosphodiesterase-4; PMA; phorbol 12-myristate 13-acet
Decrease of phosphorylated CREB and ERK in nucleus accumbens is associated with the incubation of heroin seeking induced by cues after withdrawal
Keywords: CREB; cAMP response element binding protein; ERK; extracellular regulated protein kinases; PDE4; phosphodiesterase-4; aCSF; arificial cerebrospinal fluid; Addiction; cAMP; Opioid; Phosphodiesterase-4; Transcription factor;
Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains
Keywords: PDE4; Phosphodiesterase; cAMP; cyclic AMP; Dimerization; Dimerisation; Rolipram;
Design of new hybrid template by linking quinoline, triazole and dihydroquinoline pharmacophoric groups: A greener approach to novel polyazaheterocycles as cytotoxic agents
Keywords: Quinoline; 1,2,3-Triazole; Azide; Alkyne; Cancer; PDE4;
Proinflammatory receptor switch from Gαs to Gαi signaling by β-arrestin-mediated PDE4 recruitment in mixed RA synovial cells
Keywords: Chronic arthritis; TNF; Sympathetic neurotransmitters; G protein-coupled receptors; PDE4; β-arrestin;
Synthesis of N-(3-arylprop-2-ynyl)substituted olanzapine derivatives as potential inhibitors of PDE4B
Keywords: Olanzapine; Alkyne; PDE4; Docking;
Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea
Keywords: Crotalaria ferruginea; Isoflavonoids; PDE4; SAR; Molecular dynamics simulation;
Synthesis of 2H-1,3-benzoxazin-4(3H)-one derivatives containing indole moiety: Their in vitro evaluation against PDE4B
Keywords: 2H-1,3-Benzoxazin-4(3H)-one; Indole; Benzofuran; Pd/C; PDE4;
Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors
Keywords: PDE4; PDE4B; PDE4D; Selective inhibitor; Full length; COPD;
Efficacy and safety of umeclidinium/vilanterol 62.5/25Â mcg and tiotropium 18Â mcg in chronic obstructive pulmonary disease: Results of a 24-week, randomized, controlled trial
Keywords: Long-acting bronchodilator; Umeclidinium; Vilanterol; AE; adverse event; CI; confidence interval; COPD; chronic obstructive pulmonary disease; DPI; Dry powder inhaler; FEV1; forced expiratory volume in one second; FP; fluticasone propionate; FVC; forced v
Lack of Efficacy of an Inhibitor of PDE4 in Phase 1 and 2 Trials of Patients With Nonalcoholic Steatohepatitis
Keywords: Fatty Liver Disease; Therapeutic Targets; Treatment; PDE4; AE; adverse event; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AUC; area under the plasma drug concentration time curve; AUCtau; area under the plasma drug concentration time c
Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway
Keywords: Burn injury; C2C12 myotubes; Muscle atrophy; PDE4; Signaling pathways; Torbafylline;
A modular synthesis of novel 4-amino-7,8-dihydro-1,6-naphthyridin-5(6H)-ones as PDE4 inhibitors
Keywords: PDE4; Inhibitor; Modular synthesis; Tetra-substituted; Dihydronaphthyridinone;
Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling
Keywords: βARs; β-adrenergic receptors; β-arr; β-arrestin; ANF; Atrial Natriuretic Factor; HDAC4; histone deacetylase 4; Epac; exchange protein directly activated by cAMP; Iso; isoproterenol; RA; Ras association domain; β-Adrenergic receptor subtypes; Epac; β
Receptor-mediated Ca2Â + and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin
Keywords: AKAP; A-Kinase Anchoring Protein; ATP; adenosine triphosphate; β2AR; β2-adrenergic receptor; BAPTA-AM; 1,2-Bis(2-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid tetrakis(acetoxymethyl ester); BIM; bisindolylmaleimide; [Ca2 +]i; intracellular calcium
Methylxanthines do not affect rhythmogenic preBötC inspiratory network activity but impair bursting of preBötC-driven motoneurons
Keywords: C4; fourth cervical; CPA; cyclopiazonic acid; DMPX; 3,7-dimethyl-1-propargylxanthine; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; Hepes; hydroxyethyl piperazineethanesulfonic acid; IRCs; ictal respiratory changes; P; postnatal day; PDE4; phosphodiesterase-
Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Keywords: PDE4; PDE4B; PDE4 inhibitor; cAMP; COPD; Crystallography; 2-Phenylpyrimidine;
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Keywords: PDE4; PDE4 inhibitor; PDE4B; cAMP; COPD; Anti-inflammatory agent; Crystallography; 2-Phenylpyrimidine
Montmorillonite K-10 catalyzed green synthesis of 2,6-unsubstituted dihydropyridines as potential inhibitors of PDE4
Keywords: Dihydropyridine; MCR; Montmorillonite K-10; PDE4
Inhibition of Phosphodiesterase 4 Enhances Clitoral and Vaginal Blood Flow Responses to Dorsal Clitoral Nerve Stimulation or PGE1 in Anesthetized Female Rats
Keywords: Blood Flow; Clitoris; Vagina; Doppler; PDE4; cAMP; VIP
Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor
Keywords: Moracin M; PDE4; Inhibition; Asthma; Kinetics analysis; Molecular docking; Molecular dynamics simulations;
AlCl3 induced C-arylation/cyclization in a single pot: a new route to benzofuran fused N-heterocycles of pharmacological interest
Keywords: Benzofuran; 2,3-Dichloropyrazine; AlCl3; X-ray; PDE4;
Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain
Keywords: Cyclic AMP; In situ hybridization; PDE4; PDE7; Rat; Mouse; Neuroanatomy;
Additive anti-inflammatory effects of beta 2 adrenoceptor agonists or glucocorticosteroid with roflumilast in human peripheral blood mononuclear cells
Keywords: Roflumilast; cAMP; PDE4; Salmeterol; PBMC; DexamethasonePDE4i, phosphodiesterase 4 inhibitor; COPD, chronic obstructive pulmonary disease; LABA, long-acting β2 adrenoceptor agonist; PBMC, peripheral blood mononuclear cells; TNFα, tumor necrosis factor-α;
Design and synthesis of 4-alkynyl pyrazoles as inhibitors of PDE4: A practical access via Pd/C–Cu catalysis
Keywords: Pyrazole; Alkyne; Palladium; PDE4
Conformationally restricted novel pyrazole derivatives: Synthesis of 1,8-disubstituted 5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazoles as a new class of PDE4 inhibitors
Keywords: Pyrazole; Benzo[g]indazole; PDE4; X-ray; Docking;
Pd-mediated functionalization of polysubstituted pyrroles: Their evaluation as potential inhibitors of PDE4
Keywords: Pyrrole; MCR; Palladium; Coupling; PDE4;
C-C bond formation at C-2 of a quinoline ring: Synthesis of 2-(1H-indol-3-yl)quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitors
Keywords: Quinoline; Indole; AlCl3; X-ray; PDE4;
Cyclic Adenosine Monophosphate Phosphodiesterase Type 4 Protects Against Atrial Arrhythmias
Keywords: arrhythmia; atrial fibrillation; PDE4; phosphodiesteraseAF, atrial fibrillation; β-AR, β-adrenergic receptor; cAMP, cyclic adenosine monophosphate; [cAMP]i, intracellular cyclic adenosine monophosphate; Ca2+ sparks, nonpropagating Ca2+ release; Ca2+ waves
The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity
Keywords: AMPAr; 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid receptors; CREB; cAMP response element binding protein; ERK; extracellular signal-regulated kinase; GABAr; gamma-aminobutyric acid receptor; LTP; long-term potentiation; mAChr; muscarinic ch
cAMP: Novel concepts in compartmentalised signalling
Keywords: cAMP; cyclic adenosine 3â²,5â²-monophosphate; GPCR; G protein-coupled receptor; EC coupling; excitation-contraction coupling; FRET; Förster/fluorescence resonance energy transfer; CFP; cyan fluorescent protein; YFP; yellow fluorescent protein; AKAR;