C-C bond formation at C-2 of a quinoline ring: Synthesis of 2-(1H-indol-3-yl)quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitors

Novel 2-(1H-indol-3-yl)quinoline derivatives synthesized via AlCl3-mediated C-C bond forming reaction have been identified as a new class of PDE4 inhibitors.