کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6790753 1432680 2018 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies
چکیده انگلیسی
We also review existing evidence supporting the involvement of miRNAs in MDD and the preclinical use of RNA interference (RNAi) strategies to target genes involved in antidepressant response. Many miRNAs have been associated to MDD, some of which e.g., miR-135 targets genes involved in antidepressant actions. Likewise, SSRI-conjugated siRNA evokes faster and/or more effective antidepressant-like responses. Intranasal application of sertraline-conjugated siRNAs directed to 5-HT1A receptors and SERT evoked much faster changes of pre- and postsynaptic antidepressant markers than those produced by fluoxetine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 28, Issue 4, April 2018, Pages 457-482
نویسندگان
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