Keywords: Polymorphism; PSD95; DLGAP2; Autism spectrum disorder;
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Keywords: Haloperidol; Clozapine; Aripiprazole; PSD95; Dendritic spines;
Keywords: BDNF; brain-derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CNO; clozapine-n-oxide; CNS; central nervous system; DG; dentate gyrus; DH; dorsal hippocampus; DMSO; dimethyl sulfoxide; FGF2; Fibroblast growth factor-2; FGFR; Fibroblast Gro
Keywords: Adora2a; adenosine A2a receptor; ACTH; adrenocorticotropic hormone; AVP; arginine vasopressin; α-CaMKII; Ca2+/calmodulin-dependent protein kinase II-α; β-actin; Rattus norvegicus actin, beta; cAMP; cyclic adenosine monophosphate; CORT; corticosterone;
Keywords: WT; wild-type; KO; knockout; tau-/-; homozygous tau KO; mPTP; Mitochondrial permeability transition pore; AD; Alzheimer's disease; GR; Glucocorticoid Receptor; HO; heme oxygenase; GCS; γ-glutamine cysteine synthase; ROS; reactive oxygen species; Mfn1; Mi
Keywords: AD; Alzheimer's disease; Gpx4; glutathione peroxidase 4; TAM; tamoxifen; CC; cerebral cortex; HC; hippocampus; 4-HNE; 4-hydroxynonenol; GFAP; glial fibrillary acidic protein; Iba-1; ionized calcium-binding adapter molecule-1; Syn; synaptophysin; PSD95; po
Keywords: 17β-HSD; 17β-hydroxysteroid dehydrogenase; ACh; acetylcholine; AChE; acetylcholinesterase; CA1; region 1 of hippocampus proper; CAT; catalase; ER; estrogen receptor; fEPSP; field excitatory postsynaptic potentials; GPx; glutathione peroxidase; HFS; high
Keywords: C1m; rats subjected to 1Â month of compression; C1m-D14d; rats subjected to 1Â month of compression and then decompressed for 14Â days; C1w; rats subjected to 1Â week of epidural compression; C1w-D14d; rats subjected to 1Â week of compression and then dec
Keywords: Neurotrophin; Jiadifenolide; hiPSC; Neurite outgrowth; MAP2; PSD95;
Keywords: Honokiol microemulsion; Cerebral ischemia protection; Embryo-fetal development toxicity; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; GD; gestation day; GLP; Good Laboratory Practice; ICH; International Conference on Har
Keywords: 7,8-Dihydroxyflavone (7,8-DHF); Antidepressant-like effects; Chronic mild stress (CMS); TrkB; PSD95; Synaptophysin;
Keywords: Agmatine; Antidepressants; Central nervous system; Depression; Neuroprotection; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ARE; antioxidant response element; BDNF; brain-derived-neurotrophic factor; BBB; blood-brain barrier; CRE; cAMP
Keywords: Drp1; Dynamin-related protein1; GSK3β; Glucose synthase kinase 3 beta; CDK5; Cyclin dependent kinase 5; miRNA; micro ribonucleic acid; NMDAR; N-methyl-D-aspartate receptor; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; AD; Alzhei
Keywords: HCNP; hippocampal cholinergic neurostimulating peptide; HCNP-pp; hippocampal cholinergic neurostimulating peptide precursor protein; PEBP; phosphatidylethanolamine binding protein; RKIP; raf-1 kinase inhibitory protein; CRMP-2; collapsin response mediator
Tat-HA-NR2B9c attenuate oxaliplatin-induced neuropathic pain
Keywords: Oxaliplatin; NMDAR; PSD95; Pain;
Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation
Keywords: AI; apoptosis index; ALT; alanine aminotransferase; ANOVA; analysis of variance; AST; aspartate aminotransferase; BDNF; brain-derived neurotrophic factor; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol-bis(β-aminoethyl ether)-N,N,Nâ²,Nâ²-
Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats
Keywords: CB1; cannabinoid receptor type-1; PFC; prefrontal cortex; DH; dorsal hippocampus; PND; postnatal day; AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide; CORT; corticosterone; GAD67; glutamic acid decarboxyla
Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke
Keywords: 5α-DHP; 5α-dihydroprogestrone; ABC; ATP-binding cassette; AF6; ALL-1-fused gene from chromosome 6; ALL; acute lymphoblastic leukemia; AMPAR; amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor; Ang-1; angiopoietin-1; AP-1; activator protein-1; BBB;
Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice
Keywords: AD; Alzheimer's Disease; ADP; Adenosine diphosphate; Aβ; β-amyloid; CAW; Water extract of Centella asiatica; CFR; Conditioned fear response; ETC; Electron transport chain; FCCP; Carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone; GAPDH; Glyceraldehyde
Morinda officinalis How. - A comprehensive review of traditional uses, phytochemistry and pharmacology
Keywords: MO; Morinda officinalis How.; HNMR; nuclear magnetic resonance spectroscopy; IR; infrared spectroscopy; MS; mass spectrometry; 1HNMR; urine nuclear magnetic resonance 1H; TCM; traditional Chinese medicine; SFDA; State Food and Drug Administration; i.p.; i
Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies
Keywords: Ketamine; microRNA; Prefrontal cortex; Small interfering RNA; RNA interference; 5-HT; serotonin; 5-HT1A receptor; serotonin 1A receptor; A1; adenosine A1 receptor; AchE; acetylcholinesterase; AGO; argonaute; Akt-mTOR; protein kinase B/Akt- mammalian targe
The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain
Keywords: GFAP; glial fibrillary acidic protein; HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; HMGCS1; 3-hydroxy-3-methylglutaryl-CoA synthase-1; PSD95; postsynaptic density protein 95; miRNA; astrocytes; cholesterol; aging; memory;
Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes
Keywords: Ank2; ankyrin-2; AP-2; adaptor complex 2 subunit; APP; amyloid precursor protein; AUC; area under the curve; BDNF/NT-3; brain-derived neurotrophic factor and neurotrophin-3 receptor; CDS; coding sequence; CLTB; clathrin light-chain B; EAAT1/GLAST; excitat
Critical role for Annexin A7 in secondary brain injury mediated by its phosphorylation after experimental intracerebral hemorrhage in rats
Keywords: ANXA7; Annexin A7; FJB; fluoro-jade B; ICH; intracerebral hemorrhage; NMDA receptor; N-methyl-d-aspartate receptor; PSD95; postsynaptic density protein 95; SBI; secondary brain injury; SD; Sprague Dawley; SNAP23; Synaptosome associated protein 23; SNAP25;
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway
Keywords: Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test
Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3+/âc mutant mouse model
Keywords: Autism Spectrum Disorder; Shank3; Isoflurane; NR1; PSD95;
Anxiety like behavior due to perinatal exposure to Bisphenol-A is associated with decrease in excitatory to inhibitory synaptic density of male mouse brain
Keywords: Bisphenol-A; Perinatal exposure; PSD95; Gephyrin; Synaptophysin; Anxiety;
Research reportRole of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression
Keywords: BDNF; brain-derived neurotrophic factor; MDD; major depressive disorder; CUMS; chronic unpredicted mild stress; NR2B; NMDA receptor subtype 2B; PSD95; postsynaptic density protein 95; TrkB; tropomyosin-related kinase B; BDNF; proBDNF; Depression; Stress;
Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens
Keywords: ILT; intralaminar thalamus; MSNs; medium spiny neurons; NAc; nucleus accumbens; NDS; normal donkey serum; PBS; phosphate-buffered saline; PFA; paraformaldehyde; PSD95; post-synaptic density 95; SCVS; sub-chronic variable stress; TH; tyrosine hydroxylase;
Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization
Keywords: Arc; activity-regulated cytoskeleton-associated protein; EDTA; ethylenediaminetetraacetic acid; ERK; extracellularsignal-regulated kinase; HCD; Higher-Energy Collision; HFS; high-frequency stimulation; LTP; long-term potentiation; PSD95; postsynaptic dens
Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BCA; bicinchoninic acid; CA; Cornu Ammonis; DG; Dentate Gyrus; DIV; days in vitro; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GFAP; Glial Fibrilary Acidic Protein; GFP; Green Fluorescent P
Nitric oxide/cGMP signaling via guanylyl cyclase isoform 1 modulates glutamate and GABA release in somatosensory cortex of mice
Keywords: 8-Br-PET-cGMP; 8-Bromo-β-phenyl-1, N2-ethenoguanosine-cGMP; ACSF; artificial cerebrospinal fluid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; cGMP; cyclic guanosine monophosphate; D-AP5; d-(-)-2-amino-5-phosphonopentanoic aci
Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats
Keywords: AUC; area under the curve; CNS; central nervous system; CPS; composite pain scores; eNOS; endothelial nitric oxide synthase; FLI; Fos-like immunoreactive; i.p.; intraperitoneal; NMDAR; N-methyl-d-aspartate receptor; nNOS; neuronal nitric oxide synthase; N
The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells
Keywords: PSD; post synaptic density; PSD95; post synaptic density protein 95; AKAP79/150; A kinase anchoring protein 79/150; GABAR; gamma-aminobutyric acid A receptor; AMPAR; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; NMDAR; N-methyl-d-aspa
Ischemic preconditioning protects the brain against injury via inhibiting CaMKII–nNOS signaling pathway
Keywords: Ischemic preconditioning; Neuroprotection; CaMKII; PSD95; nNOS; c-Jun; FasL
Colocalization of synapse marker proteins evaluated by STED-microscopy reveals patterns of neuronal synapse distribution in vitro
Keywords: GABA; γ-aminobutyric acid; Geph; gephyrin; PNNs; perineuronal nets; PSD95; postsynaptic density protein 95 kDa; STED; stimulated emission depletion; VGAT; vesicular γ-aminobutyric acid transporter; VGLUT1; vesicular glutamate transporter; Synapse quant
Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease
Keywords: HD; Huntington's disease; Rsk; 90-kDa ribosomal S6 kinase; AAV5; adeno-associated-virus 5; htt; huntingtin; BDNF; brain-derived neurotrophic factor; SRF; serum response factor; iEGs; immediate early-genes; GFP; green fluorescent protein; rpm; rotations pe
Spatial patterns and cell surface clusters in perineuronal nets
Keywords: PNN; perineuronal nets; CNS; central nervous system; CSPG; chondroitin sulfate proteoglycans; AMPA receptor; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; WFA; Wisteria floribunda agglutinin; GalNAc; N-acetyl-galactosamine; CS; chondroit
Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients
Keywords: Alzheimer disease; Insulin-like growth factor-1 receptor; Insulin receptor; PSD95; p75 neurotrophin receptor; tyrosine receptor kinase-A; AD; Alzheimer's disease; FBS; fetal bovine serum; HMW; high molecular weight; IGF-1R; insulin-like growth factor-1
Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration
Keywords: LRP1; low density lipoprotein receptor related-protein 1; Snx17; Sorting nexin 17; PSD95; postsynaptic density protein 95; Dab-2; disabled homolog 2; ECM; extracellular matrix; RMS; rostral migratory stream; BrdU; 5-bromo-2-deoxyuridine; CPZ; chlorpromazi
Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma
Keywords: mEPSCs/sEPSCs; miniature and spontaneous excitatory postsynaptic currents; LSPS; laser scanning photostimulation; TBI; traumatic brain injury; GAP43; growth-associated protein-43; VGLUT1; vesicular glutamate transporter1; PSD95; postsynaptic density 95; V
Fluorocitrate induced the alterations of memory-related proteins and tau hyperphosphorylation in SD rats
Keywords: FC; fluorocitrate; GSK-3β; glycogen synthase kinase-3β; pS9; phosphorylated GSK-3β at serine 9; PP2A; protein phosphatase-2A; PP2AC; PP2A catalytic subunit; pY307; phosphorylated PP2A catalytic subunit at tyrosine-307; CREB; cAMP response element bindi
Decreased expression of mGluR5 within the dorsolateral prefrontal cortex in autism and increased microglial number in mGluR5 knockout mice: Pathophysiological and neurobehavioral implications
Keywords: CAK β; cell adhesion kinase-β; CREB; cyclic AMP response binding protein; DAG; diacylglycerol; ER; endoplasmic reticulum; GKAP; guanylate kinase associated protein; Gq/Gq11; guanine nucleotide binding protein q/q11; IP3; inositol 1,4,5 trisphosphate; NM
Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol
Keywords: Aβ; amyloid β-protein; AD; Alzheimer's disease; IP; immunoprecipitation; SEC; size exclusion chromatography; AβM; Aβ monomers; AβD; LDS-stable Aβ dimers; Chiro; chiro-inositol; Scyllo; scyllo-inositol; ICC; immunocytochemistry; IHC; immunohistochemi
Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics
Keywords: NMDAR; Postsynaptic density 95; Neuronal nitric oxide synthase; Complete Freund's adjuvant; paclitaxel; Neuropathic pain; Central sensitization; motor ataxia; Allodynia; NMDAR; N-methyl-d-aspartate receptor; nNOS; neuronal nitric oxide synthase; PSD95; po
Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure
Keywords: AED; antiepileptic drugs; AMPA; a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CaMKII; Calcium/calmodulin-dependent kinase II; Dab1; Disabled-1; EPM; elevated plus maze; FMRP; Fragile X mental retardation 1 protein; GluR1; AMPA receptor subunit 1;
Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing
Keywords: AAD; active adenylation domain; 4-PBA; 4-phenylbutyric acid; 6-OHDA; 6-hydroxydopamine; ABCG5/8; ATP-binding cassette sub-family G member 5/8; AD; Alzheimer's disease; AIB1; amplified in breast cancer 1; AIP4; atrophin-1 interacting protein 4; AMPA; α-
Age-dependent neuron loss is associated with impaired adult neurogenesis in forebrain neuron-specific Dicer conditional knockout mice
Keywords: miRNA; microRNA; cKO; conditional knockout; AD; Alzheimer's disease; DG; dentate gyrus; SGZ; subgranular zone; SVZ; subventricular zone; GCL; granular cell layer; MAP2; microtubule-associated protein; SVP38; synaptophysin; GFAP; glial fibrillary acidic pr
BDNF mechanisms in late LTP formation: A synthesis and breakdown
Keywords: Brain-derived neurotrophic factor (BDNF); TrkB signaling; Synaptic plasticity; Long-term potentiation (LTP); Protein synthesis; Translation control; Cytoskeletal dynamics; Arc; activity-regulated cytoskeleton-associated protein; AS; Angelman syndrome; AS-
BDNF-induced local protein synthesis and synaptic plasticity
Keywords: Brain-derived neurotrophic factor (BDNF); Synaptic plasticity; Long-term potentiation (LTP); Translation; RNA transport; ADF; actin-depolymerizing factor; A2RE; heterogeneous nuclear ribonucleoprotein (hnRNP) A2 response element; Arc; activity-regulated c