Phosphorylation of collapsin response mediator protein-2 regulates its localization and association with hippocampal cholinergic neurostimulating peptide precursor in the hippocampus

► HCNP-pp colocalizes with unphosphorylated and pSer-522-phosphorylated CRMP-2 in the presynaptic terminals. ► pThr-509/514-CRMP-2 does not colocalize with HCNP-pp in the hippocampus. ► The phosphorylation of CRMP-2 may influence its ability to bind to HCNP-pp.