Keywords: AD; Alzheimer's disease; BBB; blood brain barrier; RAGE; Receptor for Advanced Glycation End products; AGE; advanced glycation end products; IL1β; interleukin 1 beta; Aβ; amyloid beta; TNF â;  tumor necrosis factor alpha; TGFβ; transforming growth
مقالات ISI (ترجمه نشده)
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Structural characterization of recombinant human fibroblast growth factor receptor 2b kinase domain upon interaction with omega fatty acids
Keywords: hFGFR2b; human fibroblast growth factor receptor 2b; UFAs; unsaturated fatty acids; CD; circular dichroism; FGFRs; fibroblast growth factor receptors; RTK; receptor tyrosine kinase; Ig; immunoglobulin; PLCγ; phospholipase Cγ; FRS2; fibroblast growth fac
Keywords: AD; atopic dermatitis; AMP; antimicrobial peptide; CAPS; cryopyrin-associated periodic syndrome; CPA; carboxypeptidase A; CTMC; connective tissue mast cell; dsRNA; double-stranded RNA; GF; germ-free; HSV; herpes simplex virus; Ig; immunoglobulin; IL; inte
Keywords: ATP; adenosine triphosphate; Ca2+; Â calcium; CamK; calmodulin-dependent kinase; ChREBP; carbohydrate response element binding protein; CypD; cylophilin D; DGAT2; diacylglycerol acyltransferase 2; ER; endoplasmic reticulum; FOXO1; Forkhead box O1; G6P; gl
Keywords: AFC; Annual Fuel Costs; CF; Conversion Factor; COP; Coefficient of Performance; CRF; Capital Recovery Factor; DC; Direct Costs; DFI; Discount Factor for Inflation; DR; Depreciation Rate; FCI; Fixed Capital Investment; IC; Indirect Costs; LF; Load Factor;
Keywords: Avian reovirus; Interferon induction; PKR; Apoptosis; Virus uncoating;
Keywords: OASL; 2'-5'-oligoadenylate synthetase; PKR; double-stranded RNA-dependent protein kinase; GAS; gamma-activated site; HCMV; human cytomegalovirus; ISG; IFN-I-stimulated genes; IFNAR; interferon alpha receptor; IFNGR; interferon gamma receptor; IRF; interfe
Keywords: ATF4; activating transcription factor-4; ATF6α; activating transcription factor-6α; EB1; end binding protein-1; EDEM; ER degradation-enhancing α-like protein; ER; endoplasmic reticulum; ERAD; ER-associated degradation; GCN2; general control non-derepre
Keywords: αKG; alpha ketoglutarate; BCAA/LEU; branched chain amino acids enriched with l-leucine; CHOP; C/EBP homology protein; eIF2α; eukaryotic initiation factor 2 alpha; GADD34; growth arrest and DNA damage inducible protein 34; GCN2; general control non-depre
Keywords: Bv8; Prokineticins; Oxygen-glucose deprivation; Preconditioning; Ischemic tolerance; Neuroprotection; PK2; prokineticin 2; PKR; PK receptor; PKR1; PK receptor 1; PKR2; PK receptor 2; PC7; (2-(5-(4-fluorobenzyl)-1-(4-methoxybenzyl)-1,4,5,6-tetrahydro-4,6-d
Keywords: Ribotoxic stress response; Yessotoxin; PKR; c-jun; 28S rRNA cleavage; Protein synthesis inhibition;
Keywords: APC; antigen presenting cell; BPL; beta-propiolactone; CI; confidence interval; DS; double stranded; GMC; geometric mean concentration; HA; haemagglutinin; HEK; human embryonic kidney; HI; haemagglutination inhibition assay; MPH; monovalent pooled harvest
Keywords: High-throughput screens; Translation; PKR; eIF2α; Isohymenialdisine; Hymenialdisine
Keywords: necrosis; necroptosis; RIP1; RIP3; MCMV; vaccinia; reovirus; Mycobacterium; Salmonella; Yersinia; Coxsackie B virus; cell death; innate immunity; host defense; TNF; Listeria; Human adenovirus; influenza; EPEC; PKR; IRF3
Keywords: 4E-BP1; eIF4E binding protein 1; 5â²-UTR; 5â²-untranslated region; AMPK; AMP-activated protein kinase; eIF; eukaryotic initiation factor; GCN2; general-control nonderepressible; GEF; guanine nucleotide exchange factor; GSK-3; glycogen synthase kinase-3;
Interferon α subtypes in HIV infection
Keywords: AIDS; acquired immune deficiency syndrome; APOBEC3G; apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G; ART; antiretroviral therapy; BLT; bone marrow-liver-thymus; Dpi; days post infection; HIV; human immunodeficiency virus; IDO; indoleam
A compendium of adenovirus genetic modifications for enhanced replication, oncolysis, and tumor immunosurveillance in cancer therapy
Keywords: Ad; adenovirus; ADP; adenovirus death protein; CAR; coxsackievirus and adenovirus receptor; KIR; killer inhibitory receptor; MHCI/HLA; major histocompatibility complex class I; MICA/MICB; MHC-I chain-related A and B proteins; MLP; major late promoter; MTT
PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes
Keywords: Osteoarthritis; Human chondrocyte; PKR; Oxidative stress; MMP-13;
Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells
Keywords: APCs; antigen presenting cells; BM-DCs; bone marrow-derived DCs; DCs; dendritic cells; DAMPs; danger associated molecular patterns; ELISA; enzyme-linked immunosorbent assay; FACS; fluorescence-activated cell sorting; GAPDH; glyceraldehyde-3-phosphate dehy
PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor
Keywords: Prokineticin 2β; Prokineticin receptors; G protein coupled receptor; Yeast-STAT3; Thermal hyperalgesia; Tactile allodynia; GPCR; G Protein-Coupled Receptor; PK; Prokineticin; PKR; Prokineticin Receptor; PK2β; Prokineticin 2β; ERK; Extracellular signal-
ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication
Keywords: ADAR1; adenosine deaminase acting on RNA 1; AGS; Aicardi-Goutières syndrome; APOBEC3; apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3; ds; double-stranded; dsRBD; dsRNA binding domains; eIF2α; translation initiation factor2; HIV-1; hum
Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis
Keywords: ADAMT; aggrecanase disintegrin and metalloproteinase with thrombospondin Motifs; AGE; advanced glycation end products; Akt; protein kinase B; AP; activator protein; CRP; C-reactive protein; ECM; extra cellular matrix; DAMP; damaged associated molecular pa
The role of type I interferons in innate and adaptive immunity against viruses in Atlantic salmon
Keywords: Adjuvant; DNA vaccine; Fish; IFN; ISG; TLR; CRFB; class II cytokine receptor family member; HE; hemagglutininesterase; IFN; interferon; IFN-I; type I IFN; IFNAR; mammalian type I IFN receptor; IPNV; infectious pancreatic necrosis virus; IPS-1; interferon
Ectromelia virus lacking the E3L ortholog is replication-defective and nonpathogenic but does induce protective immunity in a mouse strain susceptible to lethal mousepox
Keywords: Ectromelia virus; Mousepox virus; Double-stranded RNA; dsRNA; E3L gene; Innate immune evasion; Host range gene; PKR;
Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies
Keywords: Ketamine; microRNA; Prefrontal cortex; Small interfering RNA; RNA interference; 5-HT; serotonin; 5-HT1A receptor; serotonin 1A receptor; A1; adenosine A1 receptor; AchE; acetylcholinesterase; AGO; argonaute; Akt-mTOR; protein kinase B/Akt- mammalian targe
A potential robust antiviral defense state in the common vampire bat: Expression, induction and molecular characterization of the three interferon-stimulated genes -OAS1, ADAR1 and PKR
Keywords: Desmodus rotundus; Innate immunity; ISGs; OAS1a; OAS1b; ADAR1; PKR;
Musashi-1 promotes chemoresistant granule formation by PKR/eIF2α signalling cascade in refractory glioblastoma
Keywords: Glioblastoma multiforme; Musashi-1; PKR; Stress granule; Drug resistance;
Identification of an interferon-stimulated gene, isg15, involved in host immune defense against viral infections in gilthead seabream (Sparus aurata L.)
Keywords: Teleost; isg15 gene; Antiviral activity; SJNNV; VHSV; IFN I; Phagocytes; AGs; acidophilic granulocytes; ANOVA; analysis of variance; CPE; cytoplasmic polyadenylation element; ENA; European Nucleotide Archive; EPC; epithelioma papulosum cyprini; FBS; foeta
Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death
Keywords: Neurodegeneration; Synucleinopathies; Alpha-Synuclein; PKR; EIF2AK2; Phosphorylation; Cytotoxicity;
Grass carp (Ctenopharyngodon idella) STAT3 regulates the eIF2α phosphorylation through interaction with PKR
Keywords: STAT3; PKR; Poly I:C; eIF2α phosphorylation; Fish;
Type I interferon and HIV: Subtle balance between antiviral activity, immunopathogenesis and the microbiome
Keywords: IFN; interferon; ISGs; IFNstimulated genes; HCV; hepatitis C virus; IL-10; interleukin-10; PDL-1; programmed death-ligand 1; LCMV; lymphocytic choriomeningitis virus; IFNAR; IFNA receptor; IRFs; IFN regulatory factors; pDCs; plasmacytoid dendritic cells;
Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development
Keywords: AAF; IFN-α-activated factor; ATA; Aurintricarboxylic acid; BDV; border disease virus; BPgV; GBV-D; BVDV-1; bovine viral diarrhea virus-1; C; capsid protein; CLRs; C-type lectin receptors; Core; core protein; CSFV; classical swine fever virus; DENV; dengu
Autophagy in ischemic stroke
Keywords: 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5â²-triphosphate; BBB; blood-brain ba
Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication
Keywords: Foot-and-mouth disease virus; PKR; 3Cpro; Lysosomes;
Characterization of a PKR inhibitor from the pathogenic ranavirus, Ambystoma tigrinum virus, using a heterologous vaccinia virus system
Keywords: Innate immune evasion; dsRNA; PKR; eIF2α; Pathogenesis factor;
Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules
Keywords: SG; stress granule; Tudor-SN; Tudor staphylococcal nuclease; JNK; c-Jun N-terminal kinase; PKR; protein kinase R; PERK; PKR-like endoplasmic reticulum kinase; GCN2; general control nonderepressible 2; HRI; heme-regulated inhibitor kinase; eIF2α; eukaryot
Unravelling the structural interactions between PKR kinase domain and its small molecule inhibitors using computational approaches
Keywords: PKR; EIF2AK2; Inhibitors; Docking; 2-AP; C16; Compound 51;
Viral mouse models of multiple sclerosis and epilepsy: Marked differences in neuropathogenesis following infection with two naturally occurring variants of Theiler's virus BeAn strain
Keywords: AUC; area under curve; B6; C57BL/6; CNS; central nervous system; DA; Daniels; dpi; days post-infection; IFN; interferon; IL; interleukin; ISG; interferon-stimulated gene; PFU; plaque-forming units; pi; post-infection; PKR; protein kinase R; ROC; receiver
High glucose impairs insulin signaling via activation of PKR pathway in L6 muscle cells
Keywords: PKR; L6 muscle cells; Oxidative stress; Apoptosis;
A new role of GCN2 in the nucleolus
Keywords: GCN2; Amino acid starvation; Nucleolus; p53; RNA polymerase III; ARPP P0; acidic ribosomal phosphoprotein P0; ATF4; activating transcription factor 4; BRF1; B-related factor 1; eIF2α; eukaryotic initiation factor 2 alpha subunit; FC; fibrillar center; GA
Ctenopharyngodon idella p53 mediates between NF-κB and PKR at the transcriptional level
Keywords: p53; p65; PKR; NF-κB signaling pathway; Fish;
Altered expression of interferon-stimulated genes is strongly associated with therapeutic outcomes in hepatitis B virus infection
Keywords: Chronic hepatitis B; Antiviral therapy; IFN signaling pathway; STAT1; MX; Peg-IFN; pegylated interferon; HBeAg; hepatitis B e antigen; HBsAg; hepatitis B surface antigen; NAs; nucleot(s)ide analogues; CHB; chronic hepatitis B; ETV; entecavir; ISGs; interf
Ctenopharyngodon idella IRF2 and ATF4 down-regulate the transcriptional level of PRKRA
Keywords: PRKRA; IRF2 and ATF4; PKR; Transcriptional regulation; Grass carp;
Snapin interacts with G-protein coupled receptor PKR2
Keywords: PKR2; Snapin; Yeast two hybrid; G-protein coupled receptor; GFP; green fluorescence protein; GnRH; gonadotropin-releasing hormone; GPCRs; G protein-coupled receptors; GST; glutathione S-transferase; IHH; idiopathic hypogonadotropic hypogonadism; KS; Kallm
Heat shock increases lifetime of a small RNA and induces its accumulation in cells
Keywords: EMC; encephalomyocarditis; HSP; heat shock protein; KAC; Krebs ascites carcinoma; PFU; plaque-forming unit; PKR; protein kinase R; Pol; RNA polymerase; SINE; Short Interspersed Element; Non-coding RNA; RNA turnover; RNA decay; Heat shock; Encephalomyocard
Identification and function analysis of the three dsRBMs in the N terminal dsRBD of grass carp (Ctenopharyngodon idella) PKR
Keywords: PKR; dsRBM; Activation; Protein translation inhibition; Fish
Steroid receptor RNA activator: Biologic function and role in disease
Keywords: AF-2; activation function-2; AR; androgen receptor; C/EBPα; ccaat-enhancer-binding protein α; CTCF; CCCTC-binding factor; Ddx5; DEAD box protein 5; ERα; estrogen receptor α; GR; glucocorticoid receptor; Hes1; hairy and enhancer of split-1; HP1γ; hete
Ctenopharyngodon idella PKZ facilitates cell apoptosis through phosphorylating eIF2α
Keywords: PKZ; PKR; eIF2α; Phosphorylation; Apoptosis;
Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication
Keywords: Cytomegalovirus; PKR; Translation; Double-stranded RNA; TRS1; IRS1; Host defense;
IRE1α mediates PKR activation in response to Chlamydia trachomatis infection
Keywords: PKR; ER stress; Chlamydia;