دانلود مقالات ISI درباره Pde4 + ترجمه فارسی

Montmorillonite K-10 mediated green synthesis of cyano pyridines: Their evaluation as potential inhibitors of PDE4

Keywords: Pyridine; Montmorillonite K-10; β-keto ester; Aldehyde; Malononitrile; PDE4

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

DISC1-binding proteins in neural development, signalling and schizophrenia

Keywords: DISC1; Schizophrenia; Neurodevelopment; Signalling; Synapse; Association studies; APP; Amyloid precursor protein; ATF4; Activating transcription factor 4; BACE1; β-site APP-cleaving enzyme-1; BBS4; Bardet-Biedl syndrome 4; CEP290; Centrosomal protein 2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Novel 1-alkynyl substituted 1,2-dihydroquinoline derivatives from nimesulide (and their 2-oxo analogues): A new strategy to identify inhibitors of PDE4B

Keywords: Nimesulide; 1,2-Dihydroquinoline; Alkyne; PDE4

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2

Keywords: Phosphodiesterase inhibitors; PDE4; Thiophene; Crystallography; Gewald reaction

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors

Keywords: Azaindolines; PDE4; Inhibitors; Pyridine;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents

Keywords: PDE4; Postmortem human brain; Depression; Pleasure-seeking activity;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Beta-arrestins as regulators of signal termination and transduction: How do they determine what to scaffold?

Keywords: Arrestins; GPCR; Signaling; Chemotaxis; MAPK; PI3K; PDE4; Ubiquitin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B−/−) mice

Keywords: PDE4; cAMP; Gene knockout; Mouse; LTP; LTD; Fear conditioning; Reversal learning; Memory; Water maze

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP

Keywords: Astrocytes; Inflammation; cAMP; PDE4; β-Adrenoceptors

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitors

Keywords: PDE4; COPD; Quinoline; Cinnoline; Cynomolgus monkey; PK

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Water-soluble PDE4 inhibitors for the treatment of dry eye

Keywords: PDE4; PDE4 inhibitor; Dry eye

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Etazolate improves performance in a foraging and homing task in aged rats

Keywords: Alzheimer's disease; Etazolate; PDE4; GABA; Alpha-secretase; Cognition

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices

Keywords: Ciliary beat frequency; COPD; PDE4; Roflumilast

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The interplay between chromogranin A-derived peptides and cardiac natriuretic peptides in cardioprotection against catecholamine-evoked stress

Keywords: CgA; chromogranin A; CAs; catecholamines; NPs; natriuretic Peptides; VS-1; vasostatin 1; Cts; catestatin; rCgA1-64; rat CgA1-64; hrSTACgA1-78; human recombinant STACgA1-78; VSs; vasostatins; ET-1; endothelin 1; HPA; hypothalamus-pituitary-adrenal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

Keywords: Autophagosome; Autophagy; p62 (SQSTM1); Cyclic AMP phosphodiesterase; Rolipram; PDE4;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2010 سفارش ترجمه

Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration

Keywords: PDE4; Quinoline; Crystallography; COPD

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: Attenuation after chronic fluoxetine treatment

Keywords: cAMP; PDE4; Deer mouse; Spontaneous stereotypy; Pre-frontal cortex; Striatum; Fluoxetine; Serotonin; 5-HT1A;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors

Keywords: PDE4; PDE4 inhibitor; Triazolothiadiazines; Triazolopyridazines; Asthma; COPD

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Optimization and structure–activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of MK-0873, a potent and effective PDE4 inhibitor

Keywords: PDE4; Type 4 phosphodiesterase; 1,8-Naphthyridin-4-one-3-carboxamides; Asthma; COPD; MK-0873

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

DISC1, PDE4B, and NDE1 at the centrosome and synapse

Keywords: DISC1; PDE4; LIS1; NDEL1; NDE1; Schizophrenia; Centrosome; Synapse

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Use of a column-switching high-performance liquid chromatography method to assess the presence of specific binding of (R)- and (S)-[11C]rolipram and their labeled metabolites to the phosphodiesterase-4 enzyme in rat plasma and tissues

Keywords: 11C-Labeled metabolites; HPLC; Imaging cAMP-mediated signaling; PDE4; Positron emission tomography

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Identification of a potent new chemotype for the selective inhibition of PDE4

Keywords: PDE4; COPD; 3,4-Catechol diether

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats

Keywords: PDE4; cAMP; Phosphodiesterase; Rats; Object recognition task

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

The effects of increased cAMP content on inflammation, oxidative stress and PDE4 transcripts during Brucella melitensis infection

Keywords: Brucella melitensis; Cytokine; Forskolin; IBMX; Lipid peroxidation; Oxidative stress; PDE4; Phosphodiesterase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

How has DISC1 enabled drug discovery?

Keywords: DISC1; Psychiatric disorders; Schizophrenia; PDE4; Nudel/Ndel1; Animal models

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

A selective phosphodiesterase 4 (PDE4) inhibitor Zl-n-91 suppresses IL-17 production by human memory Th17 cells

Keywords: Th17; PDE4; Autoimmune diseases; Memory T cells

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum

Keywords: Antipsychotic drugs; Haloperidol; Clozapine; Schizophrenia; Phosphodiesterase; PDE10; PDE4; PDE1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)

Keywords: cAMP phosphodiesterase; PDE4; Rolipram; ICER; Promoter; Sp1; CRE; CREB; PKA; Cardiac myocytes; Beta-adrenoceptor; Isoprenaline; Compartmentation; Compartmentalisation

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)

Keywords: Ndel1; Nudel; cAMP phosphodiesterase; PDE4; PKA; EPAC; BRET; Phosphorylation; Rolipram; Neuronal development; DISC1; Centrosome;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Time-dependent involvement of cAMP and cGMP in consolidation of object memory: Studies using selective phosphodiesterase type 2, 4 and 5 inhibitors

Keywords: Learning and memory; Object recognition; Phosphodiesterase; Vardenafil; Rolipram; PDE2; PDE4; PDE5

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues

Keywords: PDE4; cAMP; Rolipram; Intracellular signal transduction; Myocardial imaging; Positron emission tomography

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors

Keywords: PDE4; TNF-α; c-AMP; Asthma; COPD;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Preferential inhibition of human phosphodiesterase 4 by ibudilast

Keywords: Allergic conjunctivitis; Ibudilast; Phosphodiesterase; PDE4; TNFα; LTB4; KC-404

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells

Keywords: PKA; AKAP; AKAP18; PDE4; Renal principal cells; IMCD cells

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action

Keywords: PDE4; cAMP; Object recognition; Rolipram; Acetylcholine; Memory

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Increasing synaptic noradrenaline, serotonin and histamine enhances in vivo binding of phosphodiesterase-4 inhibitor (R)-[11C]rolipram in rat brain, lung and heart

Keywords: cAMP; PDE4; Rolipram; Signal transduction; Brain and heart imaging; Positron emission tomography;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Local anti-inflammatory effect and behavioral studies on new PDE4 inhibitors

Keywords: PDE2; PDE3; PDE4; PDE5; Phosphodiesterase inhibitor; Inflammation; Pain; Locomotor activity; Pyridazinone derivatives

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579

Keywords: Oxidative stress; Phosphatidyl inositol 3-kinase; ERK; MAP kinase; cAMP; cAMP phosphodiesterase; PDE4; PDE4D3; Rolipram; Macrophage; Multi-site phosphorylation

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

Keywords: PDE4; TNF-α; c-AMP; Asthma; COPD

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions

Keywords: Asthma; roflumilast; phosphodiesterase type 4; allergen provocation; inflammation; late phase; AHR; Airway hyperresponsiveness; AUC; Area under the curve; cAMP; Cyclic adenosine monophosphate; COPD; Chronic obstructive pulmonary disease; EAR; Early asthma

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Elastolytic activity and alveolar epithelial type-1 cell damage after chronic LPS inhalation: Effects of dexamethasone and rolipram

Keywords: AHR; Airway hyperreactivity; BALF; bronchoalveolar lavage fluid; cAMP; adenosine 3′, 5′ cyclic monophosphate; COPD; chronic obstructive pulmonary disease; DMSO; dimethylsulphoxide; ECL; enhanced chemiluminescence; FEV1; Forced expiratory volume in 1 s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

2,1,3-Benzothiadiazine derivatives: synthesis and screening versus PDE4 enzyme

Keywords: 2,1,3-Benzothiadiazine; PDE4; COPD; Antioxidant activity;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation

Keywords: B-CLL; B cell chronic lymphocytic leukemia; PDE4; type 4 cAMP phosphodiesterase; Glucocorticoid therapy; B-CLL; PDE4 inhibitors; cAMP; PKA; GRE;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Phosphodiesterase 4B (PDE4B) and cAMP-level regulation within different tissue fractions of rat hippocampal slices during long-term potentiation in vitro

Keywords: ACD; Actinomycin D; CREB; cAMP-response-element-binding protein; EIA; Enzyme-immunoassay; HFS; High-frequency stimulation; LFS; Low-frequency stimulation; LTP; Long-term potentiation; NMDA; N-methyl-d-aspartate; PAGE; Poly-acrylamide gel electrophoresis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Excitability of auditory brainstem neurons, in vivo, is increased by cyclic-AMP

Keywords: cAMP, cyclic-AMP; cyclic-adenosine monophosphate; SOC; superior olivary complex; aCSF; artificial cerebrospinal fluid; Ih; hyperpolarization activated, mixed, cationic conductances; SA; spontaneous activity; ERK; extracellular signal-regulated kinase; SAP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Airway function and reactivity, leukocyte influx and nitric oxide after inoculation with parainfluenza-3 virus: effects of dexamethasone or rolipram

Keywords: AHR; airway hyperreactivity; BALF; bronchoalveolar lavage fluid; cAMP; adenosine 3′, 5′cyclic monophosphate; cNOS; constitutive nitric oxide synthase; COPD; chronic obstructive pulmonary disease; FAD; flavin adenine dinucleotide; FEV1; Forced expirato

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Treatments for COPD

Keywords: ATS; American Thoracic Society; COPD; chronic obstructive pulmonary disease; CXCR1/CXCR2; chemokine receptors 1 and 2; ERS; European Respiratory Society; FEV1; forced expiratory volume in 1 s; GOLD; Global Initiative for Chronic Obstructive Lung Disease;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

Keywords: PDE4; cyclic AMP specific phosphodiesterase-4; PKA; cyclic AMP dependent protein kinase A/A-kinase; PKA-RI; PKA type I; PKA-RII; PKA type II; AKAP; A-kinase anchor protein; Rolipram; 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; Cyclic AMP speci

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه