کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9436727 | 1615697 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Excitability of auditory brainstem neurons, in vivo, is increased by cyclic-AMP
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کلمات کلیدی
HCNWGA-HRPcAMP, cyclic-AMPERKSAPKpKaPDE4aCSFcyclic-adenosine monophosphatePSTHLSOdB SPLstandard deviation - انحراف معیارCNS - دستگاه عصبی مرکزیlateral superior olive - زیتون برتر جانبیSOC - سیستم روی یک تراشهcentral nervous system - سیستم عصبی مرکزیspontaneous activity - فعالیت خود به خودیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیsuperior olivary complex - مجتمع عالی ایلواریdecibel sound pressure level - میزان فشار صدا دسیبلpost-stimulus time histogram - هیستوگرام زمان پس از محرکStress-activated protein kinase - پروتئین کیناز فعال شده با استرسextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Physiological control of auditory neural responses is critical for accurate representation of acoustic information, such as sound source localization and speech perception. Central auditory neural responses are almost certainly regulated by a range of mechanisms, including second messenger systems, such as the cAMP pathway. An increase in spontaneous neural discharge is known to accompany cochlear insults. Here we report that an increase in spontaneous as well as tone-evoked discharge can also be induced by pressure application of forskolin, a pharmacological agent that elevates intracellular cAMP level by activating adenyl cyclase. The forskolin induced increase in superior olivary complex (SOC) brainstem neurons is specific, dose-dependent, and reversible, whereas application of artificial cerebrospinal fluid (aCSF, the vehicle) does not alter activity. Forskolin-application also has a relatively greater effect on spontaneous activity compared to tone evoked responses. Blockade of the hyperpolarization-activated current, Ih, by ZD7288, consistently reversed the effects of forskolin. Based on these findings, we propose that the second messenger, cAMP, can significantly modulate neural excitability and spontaneous discharge in SOC neurons, principally by shifting the activation of Ih channels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 201, Issues 1â2, March 2005, Pages 70-80
Journal: Hearing Research - Volume 201, Issues 1â2, March 2005, Pages 70-80
نویسندگان
Aasef G. Shaikh, Paul G. Finlayson,