کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9008095 | 1122736 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Airway function and reactivity, leukocyte influx and nitric oxide after inoculation with parainfluenza-3 virus: effects of dexamethasone or rolipram
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کلمات کلیدی
NF-κBspecific airways conductancesGawPDE4NEDcNOSPI3iNOSNOSNADPHflavin adenine dinucleotideHEPESFEV1AHRcAMP - cAMPN-[2-hydroxyethyl]piperazine-N′-[2-ethanesulfonic acid] - N- [2-hydroxyethyl] piperazine-N '- [2-ethanesulfonic acid]Parainfluenza virus type 3 - انواع ویروس پاراآنفلوآنزا 3BALF - بافتFAD - بدAirway hyperreactivity - بیش فعالی در هواپیماCOPD - بیماری مزمن انسدادی ریهChronic obstructive pulmonary disease - بیماری مزمن انسدادی ریهtumour necrosis factor-α - تومور نکروز عامل αforced expiratory volume in 1 s - حجم انسداد مجاز در 1 ثانیهDexamethasone - دگزامتازونRolipram - رولیرامامinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییconstitutive nitric oxide synthase - سنتاز اکسید نیتریک پایدارPlatelet activating factor - عامل فعال کننده پلاکتgranulocyte-macrophage colony-stimulating factor - عامل گرانولوسیت-ماکروفاژ colony-stimulating factorNuclear transcription factor-κB - فاکتور رونویسی هسته ای κBTNF-α - فاکتور نکروز توموری آلفاBronchoalveolar lavage fluid - مایع لارو برونکلوفلورRANTES - مطالبleukocyte infiltration - نفوذ لکوسیتNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازPAF - نیروی هوایی پاکستانnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphateParainfluenza virus - ویروس پاراآنفلوآنزا
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Airway function and reactivity, leukocyte influx and nitric oxide after inoculation with parainfluenza-3 virus: effects of dexamethasone or rolipram Airway function and reactivity, leukocyte influx and nitric oxide after inoculation with parainfluenza-3 virus: effects of dexamethasone or rolipram](/preview/png/9008095.png)
چکیده انگلیسی
Guinea-pigs were inoculated with parainfluenza type 3 (PI3) virus (5.2Ã107) or medium (125 μl each nostril). The PDE4-inhibitor, rolipram (1 mg kgâ1), the corticosteroid, dexamethasone (20 mg kgâ1), or vehicle were administered (i.p.) 24 h and 0.5 h before inoculation and for 4 days thereafter. Respiratory function, recorded in conscious guinea-pigs as specific airways conductance (sGaw) by whole-body plethysmography, was unaffected over 4 days by inoculation with medium or PI3. Inhaled histamine (nose-only, 1 mM, 20 s) 24 h before inoculation produced no response but 4 days after PI3 inoculation, a significant (P<0.001) bronchoconstriction occurred, indicating airway hyperreactivity (AHR). Dexamethasone or rolipram treatment inhibited the AHR. Four days after PI3- or medium-inoculation, animals underwent bronchoalveolar lavage (BAL) for total and differential (macrophages, eosinophils and neutrophils) cell counts and determination of nitric oxide (NO) as nitrite and nitrate. Compared with medium-inoculated animals, BAL fluid removed 4 days after PI3 inoculation had significantly increased macrophages, eosinophils and neutrophils. Dexamethasone or rolipram significantly (P<0.05) reduced the PI3-induced airways influx of macrophages (by 40% and 47%), eosinophils (79% and 84%) and neutrophils (58% and 61%). PI3-inoculation significantly (P<0.05) increased BALF combined NO metabolites (84.8±2.2 μM 100 μlâ1), compared with medium-inoculated (56.0±5.8) or naïve animals (45.7±2.0). Treating the PI3-infected guinea-pigs with dexamethasone or rolipram significantly (P<0.001) reduced the raised NO metabolites by 34% and 37%, respectively. These results support a role for steroids and PDE4-inhibitors in the management of inflammation and airways hyperreactivity arising from viral infection of the airways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 5, Issue 4, April 2005, Pages 771-782
Journal: International Immunopharmacology - Volume 5, Issue 4, April 2005, Pages 771-782
نویسندگان
T.J. Toward, F.J. Johnson, J.E. Boult, J.-Y. Maillard,