کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5831105 | 1559652 | 2014 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Biflavanones with anti-proliferative activity against eight human solid tumor cell lines from Stellera chamaejasme Biflavanones with anti-proliferative activity against eight human solid tumor cell lines from Stellera chamaejasme](/preview/png/5831105.png)
Six 3,3â³-biflavanones, including a new compound isochamaejasmenin C (1), were isolated from EtOH extracts of the roots of Stellera chamaejasme L. Their structures were elucidated on the basis of spectroscopic methods, including HR-ESI-MS and 2D NMR techniques. The absolute configurations on 2, 3, 3â³, and 2â³ of compounds 1, 3, and 6, which represent three geometry types of these compounds, were determined by TDDFT quantum chemical calculations of their ECD spectra. All compounds were evaluated for their cytotoxicities against eight human solid tumor cell lines and compounds 2, 4, and 6 showed strong anti-proliferative effects against all these cell lines with IC50 values ranging from 1.08 to 15.97 μM, which were in the same range as the positive control paclitaxel.
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Journal: Fitoterapia - Volume 93, March 2014, Pages 163-167