Cytotoxic sesquiterpenes and lignans from Saussurea deltoidea

Two new sesquiterpenes deltoiden A (1) and deltoiden B (2), and two new lignans deltoignan A (9) and deltoignan B (10), together with 14 known compounds, including six sesquiterpenes 3-8 and three lignans 11-13, were isolated from the whole plant of Saussurea deltoidea. Compounds 3-8 and 11-17 were isolated for the first time from this plant. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1-13 were tested against three cancer cell lines A549, Hela and SMMC-7721. Results showed that 5, 6 and 7 exhibited cytotoxicity against SMMC-7721 with the IC50 values of 6.49, 9.53, 1.23 μg/ml, 5 and 7 against A549 with the IC50 values of 4.99 and 5.35 μg/ml, 5, 6, 7, 13 against Hela with the IC50 values of 1.40, 4.75, 0.93 and 5.42 μg/ml, respectively. The structure-activity relationships of sesquiterpenes 1-8 were discussed on the base of cytotoxic results.

Two new sesquiterpenes and two new lignans together with 14 known compounds were isolated from the whole plant of Saussurea deltoidea. Some of them showed cytotoxicity against three cancer cell lines with IC50 from 0.93-9.53 μg/mL.150