کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
583314 1453170 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Degradation and metabolization of chlortetracycline during the anaerobic digestion of manure from medicated calves
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بهداشت و امنیت شیمی
پیش نمایش صفحه اول مقاله
Degradation and metabolization of chlortetracycline during the anaerobic digestion of manure from medicated calves
چکیده انگلیسی
The fate of antibiotic residues in the manure of treated animals is of considerable concern because of the potential development of antibiotic-resistant bacteria in the environment. The objective of this study was to determine the fate of chlortetracycline (CTC) during the anaerobic digestion of manure from medicated calves. Five beef calves were medicated for 5 days with 22 mg/kg/day of CTC. Manure samples collected from calves after medication were diluted 5-fold with water, loaded into triplicate 1 L anaerobic digesters and incubated at 35 °C. The CTC concentration decreased approximately 75% (from 5.9 to 1.4 ppm) during the 33 days digestion period, yielding a half-life of about 18 days. The concentration of the CTC epimer, 4-epi-chlortetracycline (ECTC), declined roughly 33% (from 4.1 to 2.5 mg/L) during anaerobic digestion. However, the concentration of the CTC metabolite, iso-chlortetracycline (ICTC), increased 2-fold (from 2.3 to 4.6 mg/L) during the digestion period. Although the water-soluble concentration of CTC decreased 84% (from 0.3 to 0.04 mg/L), the water-soluble concentrations of ECTC and ICTC increased roughly 2-fold during digestion (from 0.5 to 0.93, and 1.0 to 2.7 mg/L, respectively). Since ECTC and ICTC are more water-soluble than the parent tetracycline CTC, it is more likely that these compounds present in digested manure slurry will be detected in water monitoring samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 158, Issues 2–3, 30 October 2008, Pages 485-490
نویسندگان
,