کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5848743 | 1561704 | 2015 | 6 صفحه PDF | دانلود رایگان |
- Histological and biochemical evidence of intestinal damage seen after irradiation.
- Parameters for intestinal function measured in tissue homogenates and plasma.
- Propolis extract prevents histological and biochemical radiation-induced changes.
- Beneficial effect of propolis water extract due mainly to caffeic acid derivatives.
The ability of a specially prepared water propolis extract (PWE) to preserve the functional activity of the intestinal mucosa after radiation exposure was studied. PWE was given orally (650 mg/kg) to rats five days prior to irradiation by 6 Gy and continued for further two days. Rats were sacrificed 24 h later, intestinal segments were examined histologically and homogenates were used to assess relevant biochemical parameters reflecting intestinal injury. Irradiation led to a rise in the histological damage score, a rise in tissue TNF-α and TBARS, and a decrease in sucrase, alkaline phosphatase, GSH and cholecystokinin as well as a decrease in plasma citrulline. The findings reflect a decrease in intestinal functional activity. PWE preserved the intestinal integrity and largely protected against the changes induced in the histology damage score and all parameters measured, possibly as a result of the antioxidant and anti-inflammatory action of its caffeic acid content.
Journal: Environmental Toxicology and Pharmacology - Volume 40, Issue 3, November 2015, Pages 901-906