کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5849226 1561748 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The combined effects of developmental lead and ethanol exposure on hippocampus dependent spatial learning and memory in rats: Role of oxidative stress
ترجمه فارسی عنوان
اثرات ترکیبی اثرات سرب و اتیلن توسعه در یادگیری و حافظه فضایی وابسته به هیپوکامپ در موش صحرایی: نقش استرس اکسیداتیو
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Perinatal lead exposure impairs spatial learning and memory in rats.
- Perinatal ethanol administration impairs spatial learning and memory.
- Perinatal lead and ethanol exposure induces oxidative stress.
- Maternal consumption of ethanol during lead exposure has pronounced effects on learning and memory.

Either developmental lead or ethanol exposure can impair learning and memory via induction of oxidative stress, which results in neuronal damage. we examined the effect of combined exposure with lead and ethanol on spatial learning and memory in offspring and oxidative stress in hippocampus. Rats were exposed to lead (0.2% in drinking water) or ethanol (4 g/kg) either individually or in combination in 5th day gestation through weaning. On postnatal days (PD) 30, rats were trained with six trials per day for 6 consecutive days in the water maze. On day 37, a probe test was done. Also, oxidative stress markers in the hippocampus were also evaluated. Results demonstrated that lead + ethanol co-exposed rats exhibited higher escape latency during training trials and reduced time spent in target quadrant, higher escape location latency and average proximity in probe trial test. There was significant decrease in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and increase of malondialdehyde (MDA) levels in hippocampus of animals co-exposed to lead and ethanol compared with their individual exposures. We suggest that maternal consumption of ethanol during lead exposure has pronounced detrimental effects on memory, which may be mediated by oxidative stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 96, October 2016, Pages 263-272
نویسندگان
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