کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849323 | 1561752 | 2016 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Zinc inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in human hepatocytes (HepG2 cells) Zinc inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in human hepatocytes (HepG2 cells)](/preview/png/5849323.png)
- Zinc sources can relieve AFB1-induced cell death and DNA strand breaks in HepG2 cells.
- Zinc can moderate AFB1-induced ROS generation, nuclear changes, cell cycle arrests and apoptotic body formation.
- Zinc can ameliorate AFB1-induced epigenetic changes by mediating 8-OHdG formation and methyl oxidation of 5mdC.
- Zinc can regulate AFB1-induced biological process changes of antioxidation and apoptosis.
Aflatoxin B1 (AFB1) has strong carcinogenicity. Consumption of AFB1-contaminated agricultural products and the occurrence of hepatocellular carcinoma have received widespread attention. The aim of this paper was to investigate whether zinc supplementation could inhibit AFB1-induced cytotoxicity and genotoxicity in HepG2 cells and the mechanism of this inhibition. Our data suggest that zinc sources can relieve a certain degree of AFB1-induced cytotoxicity and genotoxicity by protecting against apoptotic body formation and DNA strand breaks, affecting S phase cell cycle arrest, reducing 8-OHdG formation, inhibiting global DNA hypomethylation and regulating gene expression in antioxidation, zinc-association and apoptosis processes. Consequently, zinc stabilizes the integrity of DNA and improves cell survival.These data provides new insights into the protective role of zinc in alleviating AFB1-induced cytotoxicity and mediating epigenetic changes in hepatocytes, demonstrating that zinc sources have detoxification properties in mycotoxin-induced toxicity.
Journal: Food and Chemical Toxicology - Volume 92, June 2016, Pages 17-25