کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849619 | 1561758 | 2015 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A comprehensive toxicological safety assessment of an aqueous extract of Polypodium leucotomos (Fernblock®)
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
EMSpsoralen-UVAPolypodium leucotomosSAZ9AABALTMPCEFOBNPDNOAELBronchus associated lymphoid tissueMMSMSDsCOA2-aminoanthracene2AASOPSPFKClPCEPLEDME9-Aminoacridine - 9-آمینواکریدینDMSO - DMSOmicronucleated polychromatic erythrocytes - erythrocytes پلی کروماتیک میکرونethyl methanesulfonate - اتیل متان سولفوناتSafety assessment - ارزیابی ایمنیpolychromatic erythrocytes - اریتروسیت های چند رنگیfunctional observation battery - باتری تابع مشاهدهanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancespecific pathogen-free - خاص بدون پاتوژنDimethyl sulfoxide - دیمتیل سولفواکسیدstandard operating procedure - روش های عملیاتی استانداردsodium azide - سدیم آیزیدToxicity - سمی بودنPhotoprotection - عکسبرداریNo observed adverse effect level - هیچ عوارض جانبی مشاهده نشدهMaterial safety data sheet - ورق ایمنی موادPuva - پیواPotassium chloride - کلرید پتاسیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A battery of toxicological studies was conducted in accordance with internationally accepted standards to investigate the genotoxicity and repeated-dose oral toxicity of Fernblock®, a commercial aqueous extraction of the leaves of the tropical fern Polypodium leucotomos used for its oral and topical photoprotective properties. No evidence of mutagenicity was observed in a bacterial reverse mutation test or in vitro mammalian chromosomal aberration test nor was any genotoxic activity observed in an in vivo mouse micronucleus test. Two repeated-dose oral toxicity studies were conducted in male and female Wistar rats. In the first study, no mortality or toxic effects were observed and no target organs were identified at doses administered for 14 days by gavage up to the maximum dose of 5000 mg/kg bw/day. Based on these results, a 90-day study was conducted at 0, 300, 600, and 1200 mg/kg bw/day. No mortality or treatment-related adverse effects were observed and no target organs were identified. The NOAEL from the 90-day study was determined to be 1200 mg/kg bw/day, the highest dose tested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 86, December 2015, Pages 328-341
Journal: Food and Chemical Toxicology - Volume 86, December 2015, Pages 328-341
نویسندگان
Timothy S. Murbach, Erzsébet Béres, Adél Vértesi, Róbert Glávits, Gábor Hirka, John R. Endres, Amy E. Clewell, Ilona Pasics Szakonyiné,