کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849633 | 1561758 | 2015 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes
ترجمه فارسی عنوان
آئروسل از یک محصول نامتجانس تغییر یافته خطر ابتلا به تداخلات دارویی باعث کاهش اثرات ممانعت شیمیایی و مهاجرت ترانسدوتلیال در مقایسه با احتراق سیگار های معمولی
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کلمات کلیدی
MRTPRTCA7-aminoactinomycin DCIM7-AADHCAECsCXCL12IL-8BSA - BSATHs - THSAtherosclerosis - آترواسکلروز(تصلب شریان)bovine serum albumin - آلبومین سرم گاوTem - این استInterleukin-8 - اینترلوکین -8Real-time cell analyzer - تجزیه کننده سلول در زمان واقعیtumor necrosis factor-α - تومور نکروز عامل αTHP-1 cells - سلول های THP-1Endothelial cells - سلولهای اندوتلیالTNF-α - فاکتور نکروز توموری آلفاModified risk tobacco product - محصول تنباکو اصلاح شدهtransendothelial migration - مهاجرت transendothelial
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Reduction of harmful constituents by heating rather than combusting tobacco is a promising new approach to reduce harmful effects associated with cigarette smoking. We investigated the effect from a new candidate modified risk tobacco product, the tobacco heating system (THS) 2.2, on the migratory behavior of monocytes in comparison with combustible 3R4F reference cigarettes. The monocytic cell line (THP-1) and human coronary arterial endothelial cells (HCAECs) were used to analyze chemotaxis and transendothelial migration (TEM). To assess the influence of aerosol extract from THS2.2 and smoke extract from 3R4F on toxicity and inflammation, flow cytometry and ELISA assays were performed. The results show that treatment of THP-1 cells with extract from 3R4F or THS2.2 induced concentration-dependent increases in cytotoxicity and inflammation. The inhibitory effects of THS2.2 extract for chemotaxis and TEM were â¼18 times less effective compared to 3R4F extract. Furthermore, extract from 3R4F or THS2.2 induced concentration-dependent decreases in the integrity of HCAEC monolayer. For all examined endpoints, the extract from 3R4F showed more than one order of magnitude stronger effects than that from THS2.2 extract. These data indicate the potential of a heat not burn tobacco product to reduce the risk for cardiovascular disease compared to combustible cigarettes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 86, December 2015, Pages 81-87
Journal: Food and Chemical Toxicology - Volume 86, December 2015, Pages 81-87
نویسندگان
Marco van der Toorn, Stefan Frentzel, Hector De Leon, Didier Goedertier, Manuel C. Peitsch, Julia Hoeng,