کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849759 | 1561763 | 2015 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment
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کلمات کلیدی
PPDsystemic exposure doseNAT1SCCPParaphenylenediamineTDANOAELMOStmaxSCCsCmaxLLOQLSCAUC - AUCHPLC/MS/MS - HPLC / MS / MSt1/2 - t1 / 2IARC یا International Agency for Research on Cancer - آژانس بین المللی تحقیقات سرطانToxicokinetics - تاکسیکوسینتیک، تاکسیکوکینتیکMargin of safety - حاشیه ایمنیLOD یا Limit of detection - حد تشخیصmaximal plasma concentration - حداکثر غلظت پلاسماHair dyes - رنگ موWorld Health Organisation - سازمان بهداشت جهانیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیliquid scintillation counting - شمارش مایع شمعدانیConsumer exposure - قرار گرفتن در معرض مصرف کنندهarea under the curve - منطقه تحت منحنیelimination rate constant - نرخ ثابت حذفelimination half-life - نیمه عمر حذفsed - وbody weight - وزن بدنWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment](/preview/png/5849759.png)
چکیده انگلیسی
Systemic exposure was measured in humans after hair dyeing with oxidative hair dyes containing 2.0% (A) or 1.0% (B) [14C]-p-phenylenediamine (PPD). Hair was dyed, rinsed, dried, clipped and shaved; blood and urine samples were collected for 48 hours after application. [14C] was measured in all materials, rinsing water, hair, plasma, urine and skin strips. Plasma and urine were also analysed by HLPC/MS/MS for PPD and its metabolites (B). Total mean recovery of radioactivity was 94.30% (A) or 96.21% (B). Mean plasma Cmax values were 132.6 or 97.4 ng [14C]-PPDeq/mL, mean AUC0-â values 1415 or 966 ng [14C]-PPDeq/mL*hr in studies A or B, respectively. Urinary excretion of [14C] mainly occurred within 24 hrs after hair colouring with a total excretion of 0.72 or 0.88% of applied radioactivity in studies A or B, respectively. Only N,Nâ²-diacetylated-PPD was detected in plasma and the urine. A TK-based human safety assessment estimated margins of safety of 23.3- or 65-fold relative to respective plasma AUC or Cmax values in rats at the NOAEL of a toxicity study. Overall, hair dyes containing PPD are unlikely to pose a health risk since they are used intermittently and systemic exposure is limited to the detoxified metabolite N,Nâ²-diacetyl-PPD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 81, July 2015, Pages 71-80
Journal: Food and Chemical Toxicology - Volume 81, July 2015, Pages 71-80
نویسندگان
Gerhard J. Nohynek, Julie A. Skare, Wim J.A. Meuling, Kenneth R. Wehmeyer, Albertus Th H.J. de Bie, Wouter H.J. Vaes, Eric K. Dufour, Rolf Fautz, Winfried Steiling, Mario Bramante, Herve Toutain,