دانلود مقالات ISI درباره نیمه عمر حذف + ترجمه فارسی

کشف یک آنتاگونیست پپتید 1 با گلوکاگون طولانی مدت با تمایل تجمع افزایش یافته

Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity

Keywords: نیمه عمر حذف; ABD3; albumin-binding domain 3; ACN; acetonitrile; AUC; area under the curve; BA; bioavailability; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary; DIEA; diisopropyl ethylene diamine; Cmax; peak plasma concentration; CLp; plasma clearance

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

مشخصات فارماکوکینتیک کاتامین های مصنوعی در یک مدل بارداری

The pharmacokinetic profile of synthetic cathinones in a pregnancy model

Keywords: نیمه عمر حذف; MDPV; 3, 4-methylenedioxypyrovalerone; LC-MS/MS; liquid chromatography-tandem mass spectrometry; Cmax; maximal concentration; Tmax; time to maximal concentration; T1/2; elimination half-life; AUC; area under the curve; Cl; clearance; Bath salts; Pregnancy

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics, tissue distribution and excretion of luteolin and its major metabolites in rats: Metabolites predominate in blood, tissues and are mainly excreted via bile

Keywords: نیمه عمر حذف; Luteolin; Metabolite; Pharmacokinetics; Bioavailability; Distribution; Excretion; ADME; absorption, distribution, metabolism and excretion; AUC; area under the curve; BCRP; breast cancer resistance protein; CE; collision energy; Cmax; peak concentration;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

اثربخشی و سمیت یک و دو بار در روز رژیم های آمیکاسین در بیماران مبتلا به سرطان کودکان ناتوپروز تب دار

Efficacy and toxicity of once versus twice daily regimens of amikacin in febrile neutropenic pediatric cancer patients

Keywords: نیمه عمر حذف; AUC24; area under the concentration time curve in 24 h; CL; clearance; Cmax; maximum concentration; Cmin; minimum concentration; FN; febrile neutropenia; Ke; elimination rate-constant; MIC; minimal inhibitory concentration; SD; standard deviation; t1/2;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

یک روش جدید برای اندازه گیری گلیکوورونید گینگرول در پلاسما یا ادرار انسان بر اساس آزمون های رقیق ایزوتوپ پایدار

A novel method for the quantitation of gingerol glucuronides in human plasma or urine based on stable isotope dilution assays

Keywords: نیمه عمر حذف; %CV; coefficient of variation; cmax; maximal plasma concentration; tmax; the time to reach cmax; AUC; area under the curve; kel; terminal elimination rate constant; t1/2; elimination half-life; SIM; selected-ion monitoring modus; HSQC; heteronuclear singl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

برآورد نیمه عمر مواد شیمیایی آلی در انسان با استفاده از دستگاه تقویت کننده شیب

Estimation of elimination half-lives of organic chemicals in humans using gradient boosting machine

Keywords: نیمه عمر حذف; Elimination half-life; Gradient boosting machine; Applicability domain; Consensus model;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2016 سفارش ترجمه

اسید گوانیدینو اسیدهای اسید خوراکی تنها دوز دارو را در داوطلبان سالم نشان می دهد

Single-dose oral guanidinoacetic acid exhibits dose-dependent pharmacokinetics in healthy volunteers

Keywords: نیمه عمر حذف; Guanidinoacetic acid; Pharmacokinetics; Area under the curve; Elimination half-life; ClearanceAUC, area under the concentration-time curve; GAA, guanidinoacetic acid; PK, pharmacokinetic

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Disappearance of R/S-methamphetamine and R/S-amphetamine from human scalp hair after discontinuation of methamphetamine abuse

Keywords: نیمه عمر حذف; R/S-methamphetamine; R/S-amphetamine; LC-MS/MS; Hair; Discontinuation; Elimination half-life;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration

Keywords: نیمه عمر حذف; Psoraleae fructus; Pharmacokinetics; Cerebral nuclei distribution; Coumarins; Prenylflavonoids; LC-MS/MS; ACN; acetonitrile; AUC; area under curve; Aβ42; β-amyloid 42; CE; collision energy; Cmax; maximum drug concentration; CMC-Na; carboxymethyl cellulo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model

Keywords: نیمه عمر حذف; AUCu; unbound area-under-the-curve; (S)-BINAP; (S)-(-)-(1,1′-binaphthalene-2,2′-diyl)bis(diphenylphosphine); CLu; unbound systemic clearance rate; Compd; compound; DIEA; N,N-diisopropyl ethylamine, EtOAc, ethyl acetate; FFA2 receptor; free fatty acid-

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine

Keywords: نیمه عمر حذف; Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacokinetic based study on “lagged stimulation” of Curcumae Longae Rhizoma - Piper nigrum couplet in their main active components' metabolism using UPLC-MS-MS

Keywords: نیمه عمر حذف; Curcumae Longae Rhizoma; Piper nigrum; UHPLC-MS-MS; Lagged stimulation; Pharmacokinetics; TCM; Traditional Chinese Medicine; Cur; curcumin; Pip; piperine; UPLC-MS-MS; ultra-performance liquid chromatography-mass spectrometry; ESI; electrospray ionizatio

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics, excretion balance, and tissue distribution of [14C]-labeled glycolipids and long chain fatty acids from Dacryopinax spathularia in rats

Keywords: نیمه عمر حذف; Jelly mushroom glycolipids; Natural preservative; Bioavailability; Long chain fatty acids; AUC; area under the concentration versus time curve; BLQ; below the quantitation limit; CMC; carboxymethylcellulose; Cmax; peak concentration; DN; dose normalized;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Toxicokinetics of perfluorooctane sulfonate in rabbits under environmentally realistic exposure conditions and comparative assessment between mammals and birds.

Keywords: نیمه عمر حذف; PFOS; Toxicokinetics; Elimination half-life; Rabbits; Comparison mammals and birds

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Application of a novel liquid chromatography/tandem mass spectrometry method for the determination of antazoline in human plasma: Result of ELEPHANT-I [ELEctrophysiological, pharmacokinetic and hemodynamic effects of PHenazolinum (ANTazoline mesylate)] hu

Keywords: نیمه عمر حذف; AF; atrial fibrillation; AN-PAF; Clinical efficacy of ANtazoline in rapid cardioversion of Paroxysmal Atrial Fibrillation: a single center, randomized, double blind, placebo-controlled study; AUCt; area under the plasma concentration-time curve from time

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Andrographis paniculata: Dissolution investigation and pharmacokinetic studies of four major active diterpenoids after multiple oral dose administration in healthy Thai volunteers

Keywords: نیمه عمر حذف; 1; andrographolide; 2; 14-deoxy-11, 12-didehydroandrographolide; 3; neoandrographolide; 4; 14-deoxyandrographolide; AUC; area under plasma concentration-time curve; Cmax; maximum concentration; Cl; clearance; EDTA; ethylenediaminetetraacetic acid; F; bioa

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo

Keywords: نیمه عمر حذف; AUC; area under the plasma concentration vs. time curve; CL; total body clearance; P450; general term for cytochrome P450 (EC 1.14.14.1); t1/2; elimination half-life; V; volume of distribution; Cynomolgus monkey; CYP2C19; Genotyping; Stereoselectivity; S-

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model

Keywords: نیمه عمر حذف; PFOS; Toxicokinetics; Elimination half-life; Birds; Gallus gallus;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Tissue specific uptake and elimination of perfluoroalkyl acids (PFAAs) in adult rainbow trout (Oncorhynchus mykiss) after dietary exposure

Keywords: نیمه عمر حذف; PFAAs; Rainbow trout; Dietary exposure; Tissue specific uptake; Elimination half-life

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment

Keywords: نیمه عمر حذف; AA; arylamine(s); AUC; area under the curve; BMI; body mass index; bw; body weight; Cmax; maximal plasma concentration; HPLC/MS/MS; high performance liquid chromatography-tandem/mass spectrometry; IARC; International Agency for the Research of Cancer; Ke;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2015 سفارش ترجمه

Liquid chromatography-tandem mass spectrometric assay for the PARP inhibitor rucaparib in plasma

Keywords: نیمه عمر حذف; AUC; area under the plasma concentration-time curve; LLOQ; lower limit of quantification; PARP; poly(ADP-ribose) polymerase; SRM; selected reaction monitoring; T1/2; elimination half-life; QC; quality control; Rucaparib; PARP inhibitor; LC-MS/MS; Plasma

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Elimination of ketoprofen from the stratum corneum after topical administration with ketoprofen formulations in human subjects

Keywords: نیمه عمر حذف; Elimination half-life; Gel formulation; Ketoprofen; Photocontact dermatitis; Tape formulation; EU; European Union; HPLC; high-performance liquid chromatography; LLOQ; lower limit of quantitation; NSAID; non-steroidal anti-inflammatory drug; PCD; photocont

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma

Keywords: نیمه عمر حذف; AUC0−∞; area under the plasma concentration-time curve; CDK; cyclin-dependent kinase; Cmax; maximum plasma concentration; EDTA; ethylenediaminetetraacetic acid; i.p.; intraperitoneal; IS; internal standard; MYCN; V-myc myelocytomatosis viral related

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles

Keywords: نیمه عمر حذف; Scutellarin; Albumin nanoparticles; Sustained release; Elimination half-life; Bioavailability

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

A UPLC-MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract

Keywords: نیمه عمر حذف; P; psoralen; IP; isopsoralen; PO; psoralenoside; IPO; isopsoralenoside; UPLC-MS/MS; ultra performance liquid chromatography tandem mass spectrometry; PCE; Psoralea corylifolia extract; PBGF; purified benzofuran glycosides fraction; TCM; traditional Chin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning

Keywords: نیمه عمر حذف; continuous veno-venous hemodialysis; elimination half-life; formate kinetics; intermittent hemodialysis; methanol kinetics; methanol poisoning;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Disappearance of 6-acetylmorphine, morphine and codeine from human scalp hair after discontinuation of opiate abuse

Keywords: نیمه عمر حذف; Opiate abuse; Segmental hair; Discontinuation; Elimination half-life

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics of Intravenous Lorazepam in Pediatric Patients with and without Status Epilepticus

Keywords: نیمه عمر حذف; CL; Clearance; Vdss; Steady state volume of distribution; ED; Emergency department; NC; Non-compartmental; SE; Status epilepticus; T1/2; Half-life; T1/2 Beta; Elimination half-life;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Elucidation of (−)-epicatechin metabolites after ingestion of chocolate by healthy humans

Keywords: نیمه عمر حذف; IS; internal standard; Cmax; maximum concentration; Tmax; maximum time; T1/2; elimination half-life; AUC; area under the curve; EC-3'-Gluc; [(-)-epicatechin-3'-β-D-glucuronide]; EC-4'-Gluc; [(-)-epicatechin-4'-β-D-glucuronide]; EC-7-Gluc; [(-)-epicatech

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia

Keywords: نیمه عمر حذف; AUC(0-∞); area under concentration-time curve from t = 0 to last time; CL/F; apparent clearance; Cmax; maximum plasma concentration; CSS; Chaihu-Shugan-San; C-t; concentration-time; FA; ferulic acid; FD; functional dyspepsia; GE; gastric empty

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Population Pharmacokinetics of Pentobarbital in Neonates, Infants, and Children after Open Heart Surgery

Keywords: نیمه عمر حذف; CL; Clearance; FOCE-I; First-order conditional estimation with interaction; PK; Pharmacokinetic; Q; Intercompartmental clearance; t1/2; Elimination half-life; Vd; Volume of distribution; V1; Volume of central compartment; V2; Volume of peripheral compartm

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Immunopharmacotherapeutic manifolds and modulation of cocaine overdose

Keywords: نیمه عمر حذف; mAb; monoclonal antibody; IgG; immunoglobulin G; Fab; Fab antibody fragment; scFv; single-chain antibody fragment; VH and VL; antibody heavy- and light-chain variable domains; GNC-BSA; GNC hapten conjugated to bovine serum albumin carrier protein; i.v.;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Poly(ethylene glycol)-Radix Ophiopogonis polysaccharide conjugates: Preparation, characterization, pharmacokinetics and in vitro bioactivity

Keywords: نیمه عمر حذف; ROP; Radix Ophiopogonis polysaccharide; mPEG; poly(ethylene glycol) monomethyl ether; FITC; Fluorescein isothiocyanate; iPjk-R; mPEG-grafted ROP with an average i mPEG (j kDa) residues per single ROP; DMAP; 4-N,N-(dimethylamino) pyridine; DMSO; dimethyl s

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Pharmacokinetic Allometric Scaling of Antibodies: Application to the First-In-Human Dose Estimation

Keywords: نیمه عمر حذف; interspecies pharmacokinetic scaling; antibodies; clearance; volume of distribution; elimination half-life; first-in-human dose;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

Application of allometric principles for the prediction of pharmacokinetics in human and veterinary drug development

Keywords: نیمه عمر حذف; Pharmacokinetic interspecies scaling; clearance; volume of distribution; elimination half-life; first-in-human dose; veterinary medicine; large animals

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2007 سفارش ترجمه

Hepatobiliary excretion and brain distribution of caffeine in rats using microdialysis

Keywords: نیمه عمر حذف; AUC; area under the concentration versus time curve; BBB; blood-brain barrier; Cl; clearance; Cmax; peak concentration; t1/2; elimination half-life; Tmax; time to reach peak concentration; Vss; volume of distribution at steady-state; Caffeine; Hepatobil

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Improved postoperative analgesia with coadministration of preoperative epidural ketamine and midazolam

Keywords: نیمه عمر حذف; Ketamine; Midazolam; Epidural; Postoperative pain; Plasma concentration; Elimination half-life

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Kinetic and cardiovascular comparison of immediate-release isradipine and sustained-release isradipine among non-treatment-seeking, cocaine-dependent individuals

Keywords: نیمه عمر حذف; AUC; area under the curve; AUC0-24; area under the serum concentration-time curve from 0 to 24 h; Clo; oral clearance; Cmax; peak serum concentration; DSM-IV; Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; HPLC; high-performanc

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Pharmacokinetics of monobutylphthalate, the active metabolite of di-n-butylphthalate, in pregnant rats

Keywords: نیمه عمر حذف; AUC; area under the concentration-time curve; CIIT; CIIT Centers for Health Research; Cls; systemic clearance; Cmax; maximum concentration; DBP; di-n-butyl phthalate; DEHP; di(2-ethylhexyl) phthalate; GD; gestation day; HPLC; high-performance liquid chr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

UDP-glucuronosyltransferases and clinical drug-drug interactions

Keywords: نیمه عمر حذف; UDP-glucuronosyltransferase; UGT1A; UGT2A; UGT2B; Glucuronidation; Drug interaction; Aet-ss; the amount of total drug excreted in urine during one dosage interval; AUCi; area under the plasma concentration-time curve in the presence of an inhibitor; AUC;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2005 سفارش ترجمه