Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma

- The first validated bioanalytical assay for AT7519 has been reported.
- The assay has successfully been validated in the 5-10,000 ng/ml range.
- The drug is sufficiently stable under all conditions relevant for the assay.
- Pharmacokinetics in mice with neuroblastoma xenografts have been reported.