کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5849784 1561762 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxicity, cell uptake and microscopic analysis of titanium dioxide and silver nanoparticles in vitro
ترجمه فارسی عنوان
سمیت سلولی، جذب سلولی و تجزیه و تحلیل میکروسکوپی نانوذرات دی اکسید تیتانیوم و نقره در آزمایشگاهی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Evaluation of the declared parameters of commercially available TiO2 NPs and Ag NPs.
- Data provided by the producers do not reflect reality.
- All of the studied NPs caused significant DNA damage and cell apoptosis.
- All the tested NPs penetrated into the SVK14 cells.

Commercially manufactured nanomaterials are used massively for modification of products of everyday use, including products intended for children. Therefore their potential risks have to be ultimately studied. Aside from toxicity of nanomaterials with known specific parameters, the end-consumer is potentially endangered by materials with unknown specification. Commercially available products are not usually accompanied by parameter/specification sheet providing the consumer with sufficient chemico-physical parameters allowing the evaluation of possible toxic effects.The aim of this work was to evaluate the declared parameters of commercially available TiO2 and Ag NPs employing chemico-physical methods and consequently in vitro cytotoxicity and genotoxicity tests performed on non-cancer cell lines. Based on the results of our complex study we can conclude that the data provided by the producers are not in good agreement with the performed measurements. Furthermore, all tested NPs penetrated into the SVK14 cells and all NPs had significant effect on the kinetics of ROS production in all cell lines (note: the ROS production has not been established as the major mechanism of cell damage elicited by Ag NPs). The study revealed greater cytotoxic potential of Ag NPs in comparison with TiO2 NPs and all of the studied NPs caused significant DNA damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 82, August 2015, Pages 106-115
نویسندگان
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