کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849866 | 1561769 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High dose of maternal folic acid supplementation is associated to infant asthma
ترجمه فارسی عنوان
دوز بالای مکمل اسید فولیک مادر با آسم نوزاد ارتباط دارد
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کلمات کلیدی
مکمل اسید فولیک، آسم نوزادان، متاآنالیز، مطالعه کنترل کایا،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
Maternal folic acid supplementation had a positive effect on preventing neural tube defects (NTDs), but its effects in infant asthma remained unclear. A hospital-based case-control study was conducted with outpatients between March 2010 and March 2011 including 150 onset infant asthma cases and 212 controls, together with a meta-analysis involving 14â438 participants, was performed. The association between maternal folic acid supplementation and the risk of infant asthma was not significant either in the meta-analysis (ORâ=â1.06, 95% CIâ=0.99-1.14) or in the case-control study (ORâ=â0.72, 95% CIâ=0.37-1.39). However, quantitative analysis of the supplementation dose demonstrated that the risk of infant asthma significantly increased for the infants whose mother were with high-dose supplementation (>72â000âµg
- d; ORâ=â3.16, 95% CIâ=1.15-8.71) after adjusting for confounding factors in the case-control study. Meanwhile, the risk of infant asthma significantly decreased for the infants whose mother were with low-dose supplementation (<36â000âµg
- d; ORâ=â0.36, 95% CIâ=0.17-0.77). A high dose of folic acid supplementation for mother during pregnancy was associated with an increased risk of infant asthma, whereas supplementation with a relatively low-dose was associated with a decreased risk of infant asthma. These findings should be further investigated in a large population.
- d; ORâ=â3.16, 95% CIâ=1.15-8.71) after adjusting for confounding factors in the case-control study. Meanwhile, the risk of infant asthma significantly decreased for the infants whose mother were with low-dose supplementation (<36â000âµg
- d; ORâ=â0.36, 95% CIâ=0.17-0.77). A high dose of folic acid supplementation for mother during pregnancy was associated with an increased risk of infant asthma, whereas supplementation with a relatively low-dose was associated with a decreased risk of infant asthma. These findings should be further investigated in a large population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 75, January 2015, Pages 88-93
Journal: Food and Chemical Toxicology - Volume 75, January 2015, Pages 88-93
نویسندگان
Liu Yang, Liwen Jiang, Meirong Bi, Xiaodong Jia, Youqing Wang, Chuan He, Yao Yao, Jun Wang, Zhiping Wang,