کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849944 | 1561766 | 2015 | 4 صفحه PDF | دانلود رایگان |
- Fumonisin B1 did not affect growth in rats.
- Fumonisin B1 increased the level of So and Sa and the Sa/So ratio in rats.
- Results suggest AdiDetox⢠can effectively reduce toxicity of fumonisin B1 in growing rats.
The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetoxâ¢) in reducing the toxic effects of fumonisin B1 (FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125âgâ±â1âg BW) were assigned to eight dietary treatments for seven days. The experiment had a 2âÃâ4 factorial arrangement with two levels of FB1 (0âmg and 15âmg of FB1/kg feed) and four levels of AdiDetox⢠(0âg, 1âg, 2âg and 5âg /kg feed) in the diet. No significant differences were observed in the growth performance among treatments (Pâ>â0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FB1 diets (Pâ<â0.0001) than in those fed the Control diet. Supplementation of AdiDetox⢠to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox⢠can effectively reduce toxicity of FB1 in growing rats.
Journal: Food and Chemical Toxicology - Volume 78, April 2015, Pages 60-63