کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5849944 1561766 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationEfficacy of AdiDetox™ in reducing the toxicity of fumonisin B1 in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Short communicationEfficacy of AdiDetox™ in reducing the toxicity of fumonisin B1 in rats
چکیده انگلیسی


- Fumonisin B1 did not affect growth in rats.
- Fumonisin B1 increased the level of So and Sa and the Sa/So ratio in rats.
- Results suggest AdiDetox™ can effectively reduce toxicity of fumonisin B1 in growing rats.

The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox™) in reducing the toxic effects of fumonisin B1 (FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g ± 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 × 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1/kg feed) and four levels of AdiDetox™ (0 g, 1 g, 2 g and 5 g /kg feed) in the diet. No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FB1 diets (P < 0.0001) than in those fed the Control diet. Supplementation of AdiDetox™ to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox™ can effectively reduce toxicity of FB1 in growing rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 78, April 2015, Pages 60-63
نویسندگان
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