کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849976 | 1561770 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A toxicological safety assessment of a standardized extract of Sceletium tortuosum (Zembrin®) in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
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![عکس صفحه اول مقاله: A toxicological safety assessment of a standardized extract of Sceletium tortuosum (Zembrin®) in rats A toxicological safety assessment of a standardized extract of Sceletium tortuosum (Zembrin®) in rats](/preview/png/5849976.png)
چکیده انگلیسی
A well-characterized standardized hydroethanolic extract of a traditionally recognized mak (mild) variety of Sceletium tortuosum, a South African plant with a long history of traditional ingestion, is marketed under the trade name Zembrin® as an ingredient for use in functional foods and dietary supplements. It is standardized to contain 0.35-0.45% total alkaloids (mesembrenone and mesembrenol â¥60%, and mesembrine <20%). A 14-day repeated oral toxicity study was conducted at 0, 250, 750, 2500, and 5000âmg/kg bw/day. A 90-day subchronic repeated oral toxicity study was conducted at 0, 100, 300, 450, and 600âmg/kg bw/day. Because S.âtortuosum has a long history of human use for relieving stress and calming, a functional observation battery, including spontaneous locomotor activity measured using LabMaster ActiMot light-beam frames system, was employed. Several parameters, such as locomotion, rearing behavior, spatial parameters, and turning behavior were investigated in the final week of the study. No mortality or treatment-related adverse effects were observed in male or female Crl:(WI)BR Wistar rats in the 14- or 90-day studies. In the 14- and 90-day studies, the NOAELs were concluded as 5000 and 600âmg/kg bw/d, respectively, the highest dose groups tested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 74, December 2014, Pages 190-199
Journal: Food and Chemical Toxicology - Volume 74, December 2014, Pages 190-199
نویسندگان
Timothy S. Murbach, Gábor Hirka, Ilona Pasics Szakonyiné, Nigel Gericke, John R. Endres,