کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850207 | 1561768 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toxicological evaluation of two flavors with modifying properties: 3-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2,2-dimethyl-N-propylpropanamide and (S)-1-(3-(((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)methyl)piperidin-1
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کلمات کلیدی
rCGliquid chromatography with mass spectrometryFDAFEMA GRASFEMAGLPFMPNOAELRMItmaxOECDGMPPCECmaxAUC - AUCLC/MS - LC / MSt1/2 - t1 / 2Good Laboratory Practices - آزمایشات خوبpolychromatic erythrocytes - اریتروسیت های چند رنگیToxicokinetics - تاکسیکوسینتیک، تاکسیکوکینتیکPlasma clearance - ترخیص پلاسماییGood Manufacturing Practices - روش های تولید خوبtime to reach Cmax - زمان برای رسیدن به CmaxFood and Drug Administration - سازمان غذا و داروOrganisation for Economic Co-operation and Development - سازمان همکاری اقتصادی و توسعهPeak plasma concentration - غلظت پلاسما در قلهPharmacokinetics - فارماکوکینتیکMethylcellulose - متیل سلولزarea under the curve - منطقه تحت منحنیEIC - مهندسانHalf-life - نیمه عمرno-observed-adverse-effect-level - هیچ نظارتی و معکوس-اثر-سطحextracted ion chromatogram - کروماتوگرافی یون استخراج شده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A toxicological evaluation of two structurally related flavors with modifying properties, 3-((4-amino-2,2-dioxido-1H- benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2,2-dimethyl-N-propylpropanamide (S6973; CAS 1093200-92-0) and (S)-1-(3-(((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)methyl)piperidin-1-yl)-3-methylbutan-1-one (S617; CAS 1469426-64-9), was completed for the purpose of assessing their safety for use in food and beverage applications. Both compounds exhibited minimal oxidative metabolism in vitro, and in rat pharmacokinetic studies, were poorly absorbed and rapidly eliminated. Neither compound exhibited genotoxic concerns. S6973 and S617 were not found to be mutagenic or clastogenic, and did not induce micronuclei in vitro or in vivo. In subchronic oral toxicity studies in rats, the no-observed-adverse-effect-levels (NOAELs) were 20âmg/kg/day and 100âmg/kg/day (highest doses tested) for S6973 and S617, respectively, when administered as a food ad-mix for 90 consecutive days. Furthermore, S617 demonstrated a lack of maternal toxicity, as well as adverse effects on fetal morphology at the highest dose tested, providing a NOAEL of 1000âmg/kg/day for both maternal toxicity and embryo/fetal development when administered orally during gestation to pregnant rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 76, February 2015, Pages 33-45
Journal: Food and Chemical Toxicology - Volume 76, February 2015, Pages 33-45
نویسندگان
Amy J. Arthur, Donald S. Karanewsky, Mike Luksic, Geoff Goodfellow, Jon Daniels,