کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850330 | 1561782 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Urinary analysis reveals high deoxynivalenol exposure in pregnant women from Croatia
ترجمه فارسی عنوان
تجزیه و تحلیل ادرار نشان می دهد قرار گرفتن در معرض دکسینوالنول بالا در زنان باردار از کرواسی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
چکیده انگلیسی
In this pilot survey the levels of various mycotoxin biomarkers were determined in third trimester pregnant women from eastern Croatia. First void urine samples were collected and analysed using a “dilute and shoot” LC-ESI-MS/MS multi biomarker method. Deoxynivalenol (DON) and its metabolites: deoxynivalenol-15-glucuronide and deoxynivalenol-3-glucuronide were detected in 97.5% of the studied samples, partly at exceptionally high levels, while ochratoxin A was found in 10% of the samples. DON exposure was primarily reflected by the presence of deoxynivalenol-15-glucuronide with a mean concentration of 120 μg Lâ1, while free DON was detected with a mean concentration of 18.3 μg Lâ1. Several highly contaminated urine samples contained a third DON conjugate, tentatively identified as deoxynivalenol-7-glucuronide by MS/MS scans. The levels of urinary DON and its metabolites measured in this study are the highest ever reported, and 48% of subjects were estimated to exceed the provisional maximum tolerable daily intake (1 μg kgâ1 b.w.).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 62, December 2013, Pages 231-237
Journal: Food and Chemical Toxicology - Volume 62, December 2013, Pages 231-237
نویسندگان
Bojan Å arkanj, Benedikt Warth, Silvio Uhlig, Wilfred A. Abia, Michael Sulyok, Tomislav Klapec, Rudolf Krska, Ines Banjari,