Apolar Laurus nobilis leaf extracts induce cytotoxicity and apoptosis towards three nervous system cell lines

- Laurus nobilis leaf CHCl3 extract and the fractions derived therefrom are in the focus of the study.
- A GC-EI-MS metabolic profiling analysis was performed.
- Cytotoxicity vs. neuronal (SK-N-BE(2)-C, SH-SY5Y) and glial (C6) cell lines were evaluated.
- Apoptosis was assessed by caspase-3 activation and DNA fragmentation assays.
- Cytotoxic extracts showed a strong OH oxidant ability.