کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850569 | 1561777 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subchronic toxicity study of β-hydroxy-β-methylbutyric free acid in Sprague-Dawley rats
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کلمات کلیدی
MCHA/G RATIOFDAGLPNOAELMCVMCHCALTmTORGGTHmbRDWAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازβ-Hydroxy-β-methylbutyrate - بتا-هیدروکسی-بتا-متیل بوتیراتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceGood Laboratory Practice - تمرین خوب آزمایشگاهیMean corpuscular volume - حجم متوسط مایعOral - دهانیFood and Drug Administration - سازمان غذا و داروToxicity - سمی بودنRed cell distribution width - عرض توزیع سلول قرمزmean corpuscular hemoglobin - متوسط هموگلوبین عضلانیRat - موش صحراییMean corpuscular hemoglobin concentration - میانگین غلظت هموگلوبین عروق کرونرAlbumin to globulin ratio - نسبت آلبومین به گلوبولینmammalian target of rapamycin - هدف پستانداران رپامایسینno-observed-adverse-effect-level - هیچ نظارتی و معکوس-اثر-سطحGamma-glutamyltransferase - گاما گلوتامیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Calcium β-hydroxy-β-methylbutyrate-monohydrate (CaHMB) is a dietary supplement used as an ergogenic aid and in functional and medical foods. A new delivery form has been developed, β-hydroxy-β-methylbutyric free acid (HMBFA), which has improved bioavailability. While the safety of CaHMB is well documented, there are few published studies demonstrating the safety of HMBFA. Because HMBFA results in greater serum levels of β-hydroxy-β-methylbutyrate (HMB) and greater clearance rates, a 91-day subchronic toxicity study was conducted in male and female Sprague-Dawley Crl:CD rats assigned to HMBFA treatments at either 0%, 0.8%, 1.6%, or 4% of the diet by weight. No deaths or untoward clinical observations, and no negative clinical chemistry or hematology were attributed to the administration of HMBFA. Gross pathology and histopathology results showed no tissue abnormalities due to HMBFA and all measures were within a normal physiological range for the animals or were expected in the population studied. In conclusion, the no-observed-adverse-event-level (NOAEL) for HMBFA was the highest level administered, 4% of the diet, which corresponded to an intake of 2.48 and 2.83 g/kg BW dâ1 in the males and females, respectively. The equivalent human dosage using body surface area conversion would be 402 and 459 mg/kg BW dâ1 for men and women, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 67, May 2014, Pages 145-153
Journal: Food and Chemical Toxicology - Volume 67, May 2014, Pages 145-153
نویسندگان
John C. Jr., Lawrence H. Arp, Lisa M. Diehl, Kelly L. Landin, Shawn M. Baier, John A. Rathmacher,