کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5850639 1561779 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemical analysis of estragole in fennel based teas and associated safety assessment using the Margin of Exposure (MOE) approach
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Chemical analysis of estragole in fennel based teas and associated safety assessment using the Margin of Exposure (MOE) approach
چکیده انگلیسی


- A safety assessment of estragole in fennel based teas was performed.
- Infusions from whole fennel fruits contained lower levels of estragole compared to infusions from fine cut fennel material.
- For adults MOEs were generally >10,000 indicating a low priority for risk management.
- MOEs for use of fennel teas marketed for children were generally <10,000 indicating a priority for risk management.
- For short term-exposure MOEs might be 3 orders of a magnitude higher and there would be no priority for risk management.

This study describes the analysis of estragole in dry fennel preparations and in infusions prepared from them and an associated safety assessment. A wide range of estragole levels of 0.15-13.3 mg/g dry fennel preparation was found. The estragole content in infusions was considerably lower ranging between 0.4 and 133.4 μg/25 mL infusion prepared from 1 g dry material. Infusions prepared from whole fennel fruits contained about 3-fold less estragole compared to infusions prepared from fine cut fennel material. Safety assessment was performed using the Margin of Exposure (MOE) approach comparing available tumour data to the estimated daily estragole intakes from the consumption of 1-3 cups fennel tea. MOEs obtained for adults generally point at a low priority for risk management, especially when one cup of fennel tea is used daily during lifetime. MOEs for use of fennel teas by children were generally <10,000 indicating a priority for risk management. However, limiting such uses to 1-2 weeks, MOEs might be 3 orders of a magnitude higher and there would be no priority for risk management. These results indicate a low priority for risk management actions for use of fennel teas especially for short-term uses proposed for the symptomatic treatment of digestive disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 65, March 2014, Pages 147-154
نویسندگان
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