Proteomic analysis identifies differentially expressed proteins after red propolis treatment in Hep-2 cells

- First report with Brazilian red propolis in 2-DE protein profile of Hep-2 cells.
- Five proteins were down-regulated in presence of 120 μg/mL of red propolis extract.
- Red propolis showed an increase in the mid- to late-stage apoptosis by TUNEL assay.
- Red propolis presented increase of late apoptosis by in situ Annexin-V analysis.