کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5850850 | 1561781 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brief communicationPilot toxicokinetic study and absolute oral bioavailability of the Fusarium mycotoxin enniatin B1 in pigs
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of present study was to reveal the toxicokinetic properties and absolute oral bioavailability of enniatin B1 in pigs. Five pigs were administered this Fusarium mycotoxin per os and intravenously in a two-way cross-over design. The toxicokinetic profile fitted a two-compartmental model. Enniatin B1 is rapidly absorbed after oral administration (T1/2a = 0.15 h, Tmax = 0.24 h) and rapidly distributed and eliminated as well (T1/2elα = 0.15 h; T1/2elβ = 1.57 h). The absolute oral bioavailability is high (90.9%), indicating a clear systemic exposure. After intravenous administration, the mycotoxin is distributed and eliminated rapidly (T1/2elα = 0.15 h; T1/2elβ = 1.13 h), in accordance with oral administration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 63, January 2014, Pages 161-165
Journal: Food and Chemical Toxicology - Volume 63, January 2014, Pages 161-165
نویسندگان
Mathias Devreese, Nathan Broekaert, Thomas De Mil, Sophie Fraeyman, Patrick De Backer, Siska Croubels,