کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5851066 1561785 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparisons of metabolic and physiological changes in rats following short term oral dosing with pesticides commonly found in food
ترجمه فارسی عنوان
مقایسه تغییرات متابولیک و فیزیولوژیک در موش صحرایی بعد از دوز دهانی خوراک کوتاه مدت با آفت کش ها که معمولا در مواد غذایی مشاهده می شود
کلمات کلیدی
ایمنی مواد غذایی، متابولومیکس، آفت کش ها، سم شناسی، دوره زمانی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Metabolomics was used to assess the effects of acute exposure to four pesticides.
- A comparison was made between metabolic based assessment and traditional methods.
- Metabolic responses were detected for each compound at each concentration.
- Growth, feeding and drinking rates were not significantly affected.
- These results demonstrate the use and sensitivity of metabolomics in food safety.

1H Nuclear Magnetic Resonance spectroscopy has been used to profile urinary metabolites in male Fischer F344 rats in order to assess the metabolic changes induced by oral exposure to two benzimidazole fungicides (carbendazim and thiabendazole) and two bipyridyllium herbicides (chlormequat and mepiquat). Exposure levels were selected to be lower than those expected to cause overt signs of toxicity. We then compared the sensitivity of the metabolomics approach to more traditional methods of toxicity assessment such as the measurement of growth and organ weights. Separate, acute exposure experiments were conducted for each pesticide to identify potential metabolic markers of exposure across four doses (and a control). Growth, organ weights and feeding/drinking rates were not significantly affected by any compounds at any dose levels tested. In contrast, metabolic responses were detected within 8 and 24 h for chlormequat and mepiquat, and after 24 h for carbendazim and thiabendazole. These results demonstrate the potential for the use of metabolomics in food toxicity testing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 59, September 2013, Pages 438-445
نویسندگان
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