کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5851156 | 1561785 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion
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کلمات کلیدی
GSHiAsMMAALTSMRHO-1Heme oxygenase-1PMRNrf2DMANQO1MDAGSH-Px - GSH-PXArsenic - آرسنیکInorganic arsenic - آرسنیک معدنیAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine Amino Transferase - آلانین آمینو ترانسفرازdimethylarsinic acid - اسید دی متیلارسینیکmonomethylarsonic acid - اسید مونومیتیلارسونیکOxidative stress - تنش اکسیداتیوantioxidant response element - عنصر پاسخ آنتی اکسیدانmalonaldehyde - مالونالدئیدARE - هستندLiver - کبدTotal arsenic - کل آرسنیکCurcumin - کورکومینGlutathione - گلوتاتیونglutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Oxidative stress is one of the major mechanisms implicated in inorganic arsenic poisoning. Curcumin is a natural phenolic compound with impressive antioxidant properties. What's more, curcumin is recently proved to exert its chemopreventive effects partly through the activation of nuclear factor (erythroid-2 related) factor 2 (Nrf2) and its antioxidant and phase II detoxifying enzymes. In vivo, we investigated the protective effects of curcumin against arsenic-induced hepatotoxicity and oxidative injuries. Our results showed that arsenic-induced elevation of serum alanine amino transferase (ALT) and aspartate aminotransferase (AST) activities, augmentation of hepatic malonaldehyde (MDA), as well as the reduction of blood and hepatic glutathione (GSH) levels, were all consistently relieved by curcumin. We also observed the involvement of curcumin in promoting arsenic methylation and urinary elimination in vivo. Furthermore, both the hepatic Nrf2 protein and two typically recognized Nrf2 downstream genes, NADP(H) quinine oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), were consistently up-regulated in curcumin-treated mice. Our study confirmed the antagonistic roles of curcumin to counteract inorganic arsenic-induced hepatic toxicity in vivo, and suggested that the potent Nrf2 activation capability might be valuable for the protective effects of curcumin against arsenic intoxication. This provides a potential useful chemopreventive dietary component for human populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 59, September 2013, Pages 739-747
Journal: Food and Chemical Toxicology - Volume 59, September 2013, Pages 739-747
نویسندگان
Shuang Gao, Xiaoxu Duan, Xin Wang, Dandan Dong, Dan Liu, Xin Li, Guifan Sun, Bing Li,