Topical application of Pleurotus eryngii extracts inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice by the regulation of Th1/Th2 balance

► Effect of Pleurotus eryngii extracts (PEE) on AD-like skin lesions was assayed. ► PEE suppressed dermatitis severity and serum levels of IgE and TARC. ► PEE suppressed mRNA expression of IL-4, IL-5, IL-13, TNF-α, and INF-γ. ► PEE reduced thickness of dermis in ear lesions. ► PEE inhibited infiltration of inflammatory cells and mast cells in ear lesions.