Platycodin D attenuates bile duct ligation-induced hepatic injury and fibrosis in mice

► The bile duct ligation (BDL) model is a well-known model for research in cholestasis. ► We evaluate the protective effect of the platycodin D (PD) on cholestasis in mice. ► During cholestasis, free radicals give damages to the liver cells and leads fibrosis. ► PD attenuated oxidative stress and pathological alteration in BDL received mice.