In vitro cytogenetic and genotoxic effects of curcumin on human peripheral blood lymphocytes

► We evaluated the in vitro genetic damage induced by curcumin to human lymphocytes. ► Concentrations from 1 to 50 μg/ml of curcumin induced chromosomal aberrations. ► Sister chromatid exchange rate was not statistically modified by curcumin. ► Contrary to proliferation index, mitotic index was increased for each concentration. ► Higher concentrations of curcumin could have a in vitro cyto and genotoxic effect.