Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs

► HMGB1 is pro-inflammatory cytokine as a late mediator of inflammation. ► Oleanolic acid (OA) was isolated from mistletoe (Viscum album) plant. ► OA inhibited LPS induced HMGB1 release. ► OA also inhibited and HMGB1-mediated inflammatory responses.