Fish oil prophylaxis attenuates rotenone-induced oxidative impairments and mitochondrial dysfunctions in rat brain

► Fish oil (FO) modulates rat brain oxidative markers. ► FO attenuates Rotenone (ROT)-induced oxidative/mitochondrial dysfunction. ► FO caused no alterations in MDA/ROS in brain regions. ► FO enhances GSH levels in brain. ► FO attenuates rotenone-induced mitochondrial dysfunctions in brain.