Alkaloid and flavonoid rich fractions of fenugreek seeds (Trigonella foenum-graecum L.) with antinociceptive and anti-inflammatory effects

► Six major fraction separated from methanolic extract of fenugreek. ► The alkaloid-rich fraction has antinociceptive effect. ► The flavonoid rich fraction has anti inflammatory activity. ► The antinociception effect of alkaloid rich fraction is similar to morphine.