Triptolide regulates T cell-mediated immunity via induction of CD11clow dendritic cell differentiation

► TPT induced differentiation of DC subsets from CD11chigh DCs to CD11clow DCs. ► TPT changed the immune functions of CD11chigh DCs and CD11clow DCs respectively. ► TPT suppressed activation and polarization of CD4+ T cells via CD11clow DCs in MLR.