In vitro and in vivo activity of gallic acid and Toona sinensis leaf extracts against HL-60 human premyelocytic leukemia

► Toona sinensis leaf extracts (TS extracts) arrested HL-60 cell growth at G1-S transition phase. ► TS extracts induced cell-cycle arrest was mediated by ROS generation in HL-60 cells. ► TS extracts inhibited VEGF expression and release in HL-60 cells. ► TS extracts delayed tumor progression in HL-60 xenograft nude mice.