Effects of long term exposure to the mycotoxin fumonisin B1 in p53 heterozygous and p53 homozygous transgenic mice

► The p53+/− mouse was used to assess the toxicity and carcinogenicity of fumonisin B1. ► Fumonisin B1 was hepatotoxic and hepatocarcinogenic to male mice. ► p53 and related pathways play a secondary role in responding to fumonisin B1. ► Responses in p53+/− mice indicate that fumonisin B1 is a non-genotoxic carcinogen. ► Hepatotoxicity BMD modelling was consistent with the NOEL for rat nephrotoxicity.