Inhibition of acrolein-stimulated MUC5AC expression by Platycodon grandiflorum root-derived saponin in A549 cells

► Platycodon grandiflorum root-derived saponin (CKS) suppresses acrolein-induced MUC5AC expression in A549 cells. ► CKS suppresses acrolein-induced ROS production. ► CKS suppresses acrolein-induced MUC5AC expression by inhibiting the activation of NF-κB via PKCδ-MAPK signaling.