Differential effects of shiitake- and white button mushroom-supplemented diets on hepatic steatosis in C57BL/6 mice

► Development of fatty liver in mice fed SM supplemented diet, but not in WBM supplemented diet. ► SM induced histological changes in the liver were reversible within two weeks of stopping SM diet. ► a moderate reduction of liver glycogen content in mice fed SM diet, but not those fed WBM diet. ► SM-induced fatty changes were confined to the liver, sparing heart and kidneys suggesting liver is the target for SM. ► SM diet did not induce hepatic, cardiac, renal hypertrophies and or atrophies.