New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides

► Jatrophanes from Euphorbia dendroides are potent multi-drug resistance modulators that are non-toxic for normal cells. ► Jatrophanes are successful in sensitization of multi-drug resistant cancer cells to paclitaxel. ► Synergy between jatrophanes and paclitaxel is followed by G2M arrest, cell death and anti-angiogenic activities.