Characterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl4 induced hepatic oxidative damage and renal failure in rats

► The Characterization of bioactive compounds of Ceratonia siliqua leaf extract. ► Ethyl acetate fraction of C. siliqua leaf presented an important antioxidant activity. ► The HPLC finger print of EACs active extract showed the presence of six phenolic compounds. ► The pre-treatment of rats with EACs prevented CCl4 induced hepatotoxicity and nephrotoxicity. ► Histopathological observations suggesting a marked protective effect of the EACs extract.