Two-generation reproductive and developmental toxicity assessment of dietary N-acetyl-L-aspartic acid in rats

► Dietary exposure to NAA at the highest dose evaluated does not cause reproductive toxicity in Sprague-Dawley® rats. ► Dietary exposure to NAA at the highest dose evaluated does not cause developmental or neurotoxicity in Sprague-Dawley® rats. ► Dietary exposure to very high doses of NAA will not cause adverse effects similar to those observed in Canavan disease.