Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells

► Dose- and time-dependent induction of apoptosis were observed when SiHa cells were treated with CH. ► CH exhibits anticancer effects by inducing apoptosis in SiHa cells. ► Apoptosis was confirmed by TUNEL Assay. ► qRT-PCR revealed, apoptosis in part by modulating tp53 and caspase-3, -8, and -9 expressions.