Identification of genes involved in the regulation of 14-deoxy-11,12-didehydroandrographolide-induced toxicity in T-47D mammary cells

► 14-Deoxy-11,12-didehydroandrographolide is cytotoxic against T-47D cells. ► It regulates genes that inhibit the cell cycle or promote cell cycle arrest. ► It regulates genes that reduce or inhibit cell proliferation and induce growth arrest. ► Microscopic analysis reveals highly vacuolated cells and structures similar to apoptotic bodies.